Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

By Vincent Fagan, Waleed M. Hussein, Mei Su, Ashwini K. Gidda, Michael R. Batzloff, Michael F. Good, Istvan Toth, Pavla Simerska

July 28, 2017

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Title

Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties

Author

Vincent Fagan, Waleed M. Hussein, Mei Su, Ashwini K. Gidda, Michael R. Batzloff, Michael F. Good, Istvan Toth, Pavla Simerska

Year

2017

Journal

ChemBioChem

Abstract

Four group A streptococcal glyco-lipopeptide vaccine candidates were prepared and characterized, each possessing different lipidic adjuvanting moieties. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody using ELISA. Three of the four vaccine candidates showed a significant induction of IgG response compared to a negative control.

Full Article

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201600639/abstract

Instrument

J-710

Keywords

Circular dichroism, Secondary structure, Biochemistry