Synthesis, characterization, structure and DNA binding aspects of a trinuclear copper(II) complex having a Cu3O core
Jnan Prakash Naskar, Bhargab Guhathakurta, Pritha Basu, Nirmalya Bandyopadhyay, Gopinatha Suresh Kumar, Miaoli Zhu, Liping Lu
Inorganica Chimica Acta
The oxime based ligand, 3-(thiophen-3-yl-methylene-hydrazono)-butan-2-one oxime, has been synthesised by the 1:1 Schiff-base condensation of diacetyl-monoxime monohydrazone with thiophene-2-carboxaldehyde in methanol. Subsequently, the trinuclear copper(II) complex was synthesized by 1:1 reaction of the above ligand with Cu(ClO4)2.6H2O. Both the ligand and complex have been characterized by C, H, N microanalyses, ESI-MS, FT-IR and UV-Vis spectra. The X-ray crystal structure of the complex has been determined. The structure revealed that the oximato bridged trinuclear copper(II) compound has a discrete Cu3O core. The DNA binding aspect of both the ligand and complex was studied by several spectroscopic techniques. The thermodynamic parameters of binding were also determined by temperature dependent fluorescence titrimetric means. The negative enthalpy and entropy change suggest that the interaction may take place via van der Waal’s interaction or hydrogen bond formation.
Circular dichroism, DNA structure, Ligand binding, Biochemistry