Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus
Jun-Wei He, Hao-Xian Liang, Hao Gao, Run-Qiao Kuang, Guo-Dong Chen, Dan Hu, Chuan-Xi Wang, Xing-Zhong Liu, Yan Li, Xin-Sheng Yao
Journal of Asian Natural Products Research
Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated on the basis of HR-MS, NMR, and X-ray diffraction analysis. The absolute configuration of1 was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra. Its cytotoxic effects on five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), and antimicrobial activity againstEscherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger were evaluated. This is the first report of the presence of nardosinane-type sesquiterpene inTalaromyces sp.
Circular dichroism, Absolute configuration, Natural products