Effects of lithospermic acid on hIAPP aggregation and amyloid-induced cytotoxicity by multiple analytical methods

2019 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

The abnormal aggregation of human islet amyloid polypeptide (hIAPP) is a crucial pathogenic factor associated with type 2 diabetes (T2D). …

Leah Pandiscia, PhD

Evaluation of the stereoselectivity for titanium(IV)-based coordination entities induced by the enantiopure diphenylethene-1,2-diamine ligand

2019 / Inorganica Chimica Acta

This article describes the formation of neutral TiO4N2-based coordination entities where the titanium centers are coordinated by oxygenated ligands incorporating …

Leah Pandiscia, PhD

Platelet-driven formation of interface peptide nano-network biosensor enabling a non-invasive means for early detection of Alzheimer’s disease

2019 / Biosensors and Bioelectronics

Soft material fabricated with DNA origami or peptide cross-linking technique may be promising theranostic platforms in the future; however, their …

Leah Pandiscia, PhD

Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities

2019 / Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

HOP is a cochaperone belonging to the foldosome, a system formed by the cytoplasmic Hsp70 and Hsp90 chaperones. HOP acts …

Leah Pandiscia, PhD

Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled–Coil Fusion Complex

2019 / Journal of Medicinal Chemistry

Short peptide-based inhibition of fusion remains an attractive goal in antihuman immunodeficiency virus (HIV) research based on its potential for …

Leah Pandiscia, PhD

Novel aminoquinoline-based solvatochromic fluorescence probe: Interaction with albumin, lysozyme and characterization of amyloid fibrils

2020 / Dyes and Pigments

A novel aminoquinoline derivative (AQ) was synthesized and applied as a solvatochromic fluorescent probe to study proteins and their alterations. AQ is …

Leah Pandiscia, PhD