Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors – Studying the Effect of Linker Length and Glycosylation on Their Function

2016 / Chemical Biology and Drug Design

HirudinP6 is a glycosylated and sulfated high affinity thrombin inhibitory protein isolated from Hirudineria manillensis. In this study, designing of novel… Continue reading Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors – Studying the Effect of Linker Length and Glycosylation on Their Function

Leah Pandiscia, PhD

Dissecting the structure-function relationship of a fungicidal peptide derived from the constant region of human immunoglobulins

2016 / Antimicrobial Agents and Chemotherapy

Synthetic peptides encompassing sequences related to the complementarity-determining regions of antibodies or derived from their constant region (Fc peptides) were… Continue reading Dissecting the structure-function relationship of a fungicidal peptide derived from the constant region of human immunoglobulins

Leah Pandiscia, PhD

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds

2016 / International Journal of Biological Macromolecules

Three new diphenylsubstituted spirotriazolidine- and thiazolidinone–acridines were prepared and their interaction with calf thymus DNA investigated with UV–vis, fluorescence, circular… Continue reading New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds

Leah Pandiscia, PhD

Emulsification-Induced Homohelicity in Racemic Helical Polymer for Preparing Optically Active Helical Polymer Nanoparticles

2016 / Macromolecular Rapid Communications

Optically active nano- and microparticles have constituted a significant category of advanced functional materials. However, constructing optically active particles derived… Continue reading Emulsification-Induced Homohelicity in Racemic Helical Polymer for Preparing Optically Active Helical Polymer Nanoparticles

Leah Pandiscia, PhD

Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques

2016 / Scientific Reports

Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors implicated in secondary complications of diabetes.… Continue reading Green synthesis of silver nanoparticles and characterization of their inhibitory effects on AGEs formation using biophysical techniques

Leah Pandiscia, PhD

Tempo-spatial chirogenesis. Limonene-induced mirror symmetry breaking of Sisingle bondSi bond polymers during aggregation in chiral fluidic media

2016 / Journal of Photochemistry and Photobiology A: Chemistry

Herein, we designed photoluminescent polymer aggregates surrounded by organic media containing (S)-/(R)-limonene and (1S)-/(1R)-α-pinene as an artificial model of an… Continue reading Tempo-spatial chirogenesis. Limonene-induced mirror symmetry breaking of Sisingle bondSi bond polymers during aggregation in chiral fluidic media

Leah Pandiscia, PhD