Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase
Gui-Yang Xia, Ling-Yan Wang, Jing-Fang Zhang, Yu-Zhuo Wu, Guang-Bo Ge, Ya-Nan Wang, Peng-Cheng Lin, Sheng Lin
Chinese Journal of Natural Medicines
Purpurolides D–F (1–3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, 13C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1–3 showed significant inhibitory activity against pancreatic lipase (PL). The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.
Circular dichroism, Absolute configuration, Absorption, Quantitation, Natural products, Medicinal