Title
Triterpenoids from the barks of Juglans hopeiensis
Author
Xiaogang Peng, Yi Lin, Jingjing Liang, Ming Zhou, Jia Zhou, Hanli Ruan
Year
2020
Journal
Phytochemistry
Abstract
Nine undescribed triterpenoids (jughopenoids A-I), including seven nortriterpenoids and two normal triterpenoids, together with fourteen known analogues, were isolated from the barks of Juglans hopeiensis Hu. The structures of the undescribed triterpenoids were established by integrated spectroscopic analysis and single crystal X-ray diffraction. Jughopenoid A represented an unprecedented lupane-type nortriterpenoid with a five-membered lactone ring A. Selected isolates were tested for their cytotoxic effects against human HT-29 colon carcinoma, human HepG2 hepatocellular carcinoma, and human PC-3 prostate cancer cell lines. Their immunosuppressive activities against ConA-induced T cell proliferation and LPS-induced B cell proliferation were also evaluated.
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Absolute configuration, Natural products