Title
Two New Phenolics from Danshen Injection with Antioxidant Activity
Author
Jing Liu, Yang Liu, Zhong Dai, Gang-Li Wang, Shuang-Cheng Ma
Year
2018
Journal
Chemistry of Natural Compounds
Abstract
Danshen Injection (lyophilized powder) is an important clinical preparation with therapeutic effects for cardiovascular diseases in China. Phenolics are considered to be the active ingredients. To investigate the chemical constituents of the injection and assay their antioxidant activities, several column chromatographies were applied to purify and isolate the main chemical constituents of the injection. As a result, two novel phenolic compounds, salvialdehyde acid (1) and glycerol monosalvialdehyde acid ester (2), were isolated. Free radical scavenging activity screening by DPPH· and ABTS·+ methods in vitro indicated compound 1possessed moderate antioxidant activity.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical