Title
Unusual cadinane-type sesquiterpene glycosides with α-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc.
Author
Jun He, Jie-kun Xu, Xue-ge Pan, Xian-sheng Ye, Pin-yi Gao, Yu Yan, Chun-yang Xu, Gui-fen Qiang, Guan-hua Du, Yung-Chi Cheng, Wei-ku Zhang
Year
2019
Journal
Bioorganic Chemistry
Abstract
Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E (1–5) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Their structures, which possess a naphthalene skeleton, are the first report on the occurrence of cadinane sesquiterpene glycosides in Cornus. Additionally, all the compounds exhibited marked α-glucosidase inhibitory activity except for 3in vitro.
Instrument
J-815
Keywords
Circular dichroism, Cotton effect, Absolute configuration, Natural products, Medicinal