Higher-Order Structure (HOS) Analysis of CBN-Binding DNA Aptamer using CD Spectroscopy | POSTER
January 3, 2024Introduction
DNA aptamers, which are single-stranded DNA oligonucleotides, are perceived as promising alternative chemical receptors to antibodies. They bind to specific ligands as a result of folding of tertiary structures. DNA aptamers are generally screened from DNA libraries through SELEX (systematic evolution of ligands by exponential enrichment). Using this method, Yu et al. developed a DNA aptamer for (-)-trans-Δ9-tetrahydrocannabinol (THC) and cannabinol (CBN).1) THC and CBN are two of the more than 100 types of natural chemical components called cannabinoids found in the cannabis plant. CBN is a mildly psychoactive component and is slowly gaining popularity for its potential benefits for sleep and pain management.
References
Satoko Suzuki1,2, Ai Yamane1, Taiji Oyama1, Ken-ichi Akao1, Takehiko Wada2
1. JASCO Corporation, 2967-5 Ishikawa-machi, Hachioji, Tokyo 192-8537
2. Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577