The concept of the integrated LC-4000 Series HPLC
The LC-4000 has key separation platforms at 50MPa for conventional HPLC (3, 5 and 10 μm columns), at 70MPa for RHPLC (intermediate columns such as 2 to 3 μm and ‘coreshell’) and at 130MP for UHPLC (sub 2μm).
Advances in Solvent Delivery
For more nearly three decades JASCO analytical HPLC pumps have employed an asymmetric twin-piston solvent delivery system SSQD (Slow Suction, Quick Delivery) which provides significantly better flow and pressure profiles than other conventional twin-piston reciprocating design. In the LC-4000 Series, SSQD has been re-developed, with a completely new solvent delivery mechanism ExReFT (Extremely Reliable Flow Technology) offering the highest stability in solvent delivery across the entire analytical flow rate range used in the PU-4180/85 RHPLC and PU-4280/85 UHPLC pump models.
Pioneering Optical Design
As a pioneer in optical spectroscopy, JASCO has access to optical designs that few can match. Taking advantage of our more powerful spectrometers, we have developed a range of HPLC detectors with unrivaled performance, like the new class leading FP-4020 fluorescence detector (water Raman S/N > 2300:1), the latest high-speed refractive index detector with micro cell optimized for UHPLC and the unique circular dichroism detector for chiral chromatography.
New Technologies for Method Development
With the range of column technologies becoming increasingly diverse – the traditional 5μm fully porous particle is finally losing ground to some of the newer technologies such as the new superficially porous solid core (Coreshell) and the wide variety of sub-2μm particles – the requirements for method development are becoming more demanding. Designed to accommodate analytical, preparative and multiple columns at every scale with options for integrated 6 or 10 solvent and column selection valves. The LC-4000 Series has a number of newly developed accessories to make better separations faster.
Compact and Easy to Use
Despite the extra power delivered by the LC-4000 Series HPLC, the standard footprint is only 300 mm wide – a standard system requires only a very small amount of bench space. For easy maintenance, all LC-4000 instruments feature front-panel access for replacing consumables such as pump components and light sources. The autosampler consumables such as the syringe parts are easy to access. For users requiring front-panel control, the LC-4000 Series retains a keypad and backlit LED display. Keypad control can still be configured for convenient override when under PC control.
Each LC-4000 module is designed for easy maintenance. The LC-4000 Series pump module requires smaller bench space than ordinary HPLC pumps. An integrated solvent delivery system can be incorporated into a single pump module.