Semi-Preparative SFC System Configurations

SFC-4000 Series

Semi-Preparative SFC

The semi-prep SFC has capacity for larger scale purification, but can still be used for analytical scale method development. The system is optimized for 10mm and 20mm ID columns. The open-bed fraction collector can be triggered on time, threshold or slope based on signals from up to 4 different detectors signals including UV, PDA, fluorescence, CD and/or MS. The macro cyclone separators provide simple gas-liquid separation for excellent fraction recoveries typically greater than 95%. Fractions can be collected using an open bed fraction collector or an 8-way valve.

Semi-Preparative Flow Rates

Using columns for 10 mm and 20mm ID, the semi-preparative SFC System can be used for separation and purification  of 10 to 100 grams of sample material.

Typical Purification Range

Semi-preparative flow rates from 3mL/min to 50mL/min for purification of up to 100g of sample.

Column Switching

Six or ten column switching for automatic selection.

Solvent Switching

Six or ten modifier solvent selection.

High-Capacity Column Oven

High capacity column oven for up to three 20mm columns.

High Recovery Rate

Patented individual MCS MicroCyclone fraction collection system for sample collection without cross contamination.

Powerful Software

ChromNav for simple control with powerful fractionation algorithms.

Wide Range of Detectors

Wide range of detectors including UV-visible, Photo Diode Array (PDA), Mass Spectrometer (MS),  Flame Ionization Detector (FID), and Circular Dichroism (CD) for chiral applications.  For applications that require the utmost sensitivity, JASCO has designed the first high-pressure flow cell for the FP-4020 fluorescence detector making it compatible with SFC.

High-Throughput Fraction Collection System

Fraction collection with open bed fraction collector.

Dynamic Back Pressure Regulator

Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.