Supercritical Fluid Chromatography (SFC) Systems

SFC-4000 Series

Used in both chiral and achiral chromatography, from simple analytical separations for routine analysis and method development through to preparative systems at larger scales using from 1cm to 3cm ID columns.

Supercritical Fluid Chromatography Systems
Analytical SFC System

Supercritical Fluid Chromatography (SFC)

The use of Supercritical Fluid Chromatography (SFC) is a green alternative to traditional High-Performance Liquid Chromatography (HPLC), with the use of CO2 taking the place of the organic solvent as the mobile phase. CO2 has benefits for cost, health & safety, as well as faster, cleaner sample recovery during sample purification. Other advantages of supercritical fluids include low viscosity with liquid-like densities, for higher solubility and increased column loading. The low viscosity and high diffusion lead to faster separations and faster extractions.

SFC has long been the method of choice for chiral separations, but with a large (and rapidly growing) range of column phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.

SystemColumn IDCO2 Flow RateInjection Capacity
Analytical3mm, 4.6mm0.2 - 10mLAnalytical
Hybrid4.6mm, 10mm0.5 - 20mLAnalytical to 100mg
Semi-Preparative4.6mm, 10mm, 20mm3.0 - 50mL100mg to 100 grams
Preparative10mm, 20mm, 30mm5.0 - 150mLUp to 500 grams

JASCO SFC System Advantage


JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

Fast Response Back Pressure Regulator

The BP-4340 high-speed dynamic back-pressure regulator ensures an accurate and constant back pressure (typically within a few psi), regardless of flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and precipitation build-up in the flow line.

Wide Range of Detectors

Fluorescence, UV-visible, Photometric Diode Array (PDA) and Chiral optical detectors. Non-optical detectors include Flame Ionization Detector (FID) and single-quadrupole mass spectrometer.

Find out more about the detectors here


All SF-4000 series SFC systems can be used for HPLC – simply switch off the cooling and BPR.

Integrated Modular System

A basic system for each scale can be adapted to suit any application. From modifier selection to column heater type to detector combinations.


JASCO SFC systems are compatible with most Mass Spectrometers and offer integrated control with both Advion CMS and Sciex Analyst.

Flexible Configurations

The three individual platforms for analytical, semi-prep, and preparative scales can be customized to suit all applications.