Supercritical Fluid Chromatography SFC Systems

The SF-4000 Series of SFC systems are used in both chiral and achiral chromatography, from simple analytical separations for routine analyisis and method development through to preparative systems at scales using from 1cm to 3cm ID columns.

Supercritical Fluid Chromatography Systems
Analytical SFC System

Supercritical Fluid Chromatography

The use of supercritical fluid chromatography is a green alternative to traditional HPLC, with the use of CO2 taking the place of organic solvent as the mobile phase. CO2  has benefits for cost, health, and safety, as well as faster, cleaner sample recovery during sample purification. Other advantages of supercritical fluid chromatography include low viscosity with liquid-like densities, for higher solubility and increased column loading. The low viscosity and high diffusion lead to faster separations and faster extractions.

SFC has long been the method of choice for chiral separations, but with a large (and rapidly growing) range of column phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.

JASCO SFC System Advantage

Optimized

JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

Fast Response Back Pressure Regulator

The BP-4340 high-speed dynamic back-pressure regulator ensures an accurate and constant back pressure (typically within a few psi), regardless of flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and precipitation build-up in the flow line.

Wide Range of Detectors

Dual wavelength UV-visible, PDA and the CD-4095 are the only chiral detectors suitable for SFC. Non-optical detectors include FID, ELSD and single-quad mass-spec. And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell for our fluorescence detectors making them compatible with SFC.

Find out more about the detectors here

Flexible

All SF-4000 series SFC systems can be used for HPLC – simply switch off the cooling and BPR.

Integrated Modular System

A basic system for each scale can be adapted to suit your application. From modifier selection to column heater type to detector combinations.

Compatible

JASCO SFC systems are compatible with most Mass Spectrometers and offer direct control with both Advion CMS and Sciex Analyst.

Flexible Configurations

The three individual platforms for analytical, semi-prep and preparative scales can be customized to suit all applications, just let us know what you are planning. We also provide individual modules with serial communications with a simple protocol.