Benefits of using Supercritical Fluid Systems for Separation

High Solubility & Low Viscosity

Greater solubility and lower viscosity than liquid phase HPLC for faster column equilibration, faster separations and higher productivity.

Wide Molecular Structure Coverage

Applicable to a wide range of molecular structures with a wide range of polarities from strongly hydrophobic to strongly hydrophilic.


SFC uses ‘green’ separation solvents – generally CO2 with alcoholic modifiers – which are much greener than other solvents generally used in HPLC.


Dramatic reduction in solvent costs for both purchase and disposal.

Simple Operation

SFC easily scales-up from analytical to preparative, method transfer is simple and robust for both chiral and achiral sample purification.