Title
A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis
Author
Xiao-Xiao Zhang, Shuang-Cheng Ma, Peng Mao, Ya-Dan Wang
Year
2016
Journal
Chinese Chemical Letters
Abstract
One new bisbenzylisoquinoline alkaloid, neferine N-oxide (1), along with three known compounds, neferine (2), liensinine (3), and isoliensinine (4), were isolated from Plumulanelumbinis – the embryo of the seed of Nelumbonucifera. Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, NMR), and the absolute configurations were determined by experimental circular dichroism (CD) spectra. Compound 1 is a new naturally occurring bisbenzylisoquinoline alkaloid with an N-oxide functionality, and the CD spectrum of (1R, 1′R) neferine is first reported. The antioxidant activities of compounds 1–4 were evaluated using the ORAC assay, which illustrated that all these compounds showed the different levels of oxygen radical absorbance capacity.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal, Pharmaceutical