Found 8360 Results / Page 1 of 418
2021 / Nucleic Acids Research
Rational design of aptamers to incorporate unnatural nucleotides and special chemical moieties can expand their functional complexity and diversity. Spiegelmer …
Continue reading “Circular L-RNA aptamer promotes target recognition and controls gene activity”
2021 / Nature Communications
The critical dimension of semiconductor devices is approaching the single-nm regime, and a variety of practical devices of this scale …
2021 / Nature Communications
In living organisms, proteins are organized prevalently through a self-association mechanism to form dimers and oligomers, which often confer new …
2021 / npj 2D Materials and Applications
We report the study of two-dimensional graphitic carbon nitride (GCN) functionalized with copper single atoms as a catalyst for the …
Continue reading “Copper single-atoms embedded in 2D graphitic carbon nitride for the CO2 reduction”
2021 / Scientific reports
Generally, intermolecular disulfide bond contribute to the conformational protein stability. To identify sites where intermolecular disulfide bond can be introduced …
2021 / Nature Communications
Histopathological level imaging in a non-invasive manner is important for clinical diagnosis, which has been a tremendous challenge for current …
2021 / Nature Communications
High-entropy alloys (HEAs) have been intensively pursued as potentially advanced materials because of their exceptional properties. However, the facile fabrication …
2021 / Scientific reports
In this investigation, we report the effect on the microscopic dynamics and interactions of the cytokine interferon gamma (IFN-γ) and …
2021 / Nature Communications
We previously elucidated principles for designing ideal proteins with completely consistent local and non-local interactions which have enabled the design …
Continue reading “Role of backbone strain in de novo design of complex α/β protein structures”
2021 / Scientific reports
Colistin resistance is complex and multifactorial. DbcA is an inner membrane protein belonging to the DedA superfamily required for maintaining …
Continue reading “A link between pH homeostasis and colistin resistance in bacteria”
2021 / Scientific reports
Over the past few years, biogenic methods for designing silver nanocomposites are in limelight due to their ability to generate …
2021 / Scientific reports
Sequence variants (SV) in protein bio therapeutics can be categorized as unwanted impurities and may raise serious concerns in efficacy …
2021 / Biomolecules
Natural products have been fundamental materials in drug discovery. Traditional strategies for observing natural products with novel structure and/or biological …
2021 / Nature Communications
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is …
Continue reading “Site-specific ubiquitylation acts as a regulator of linker histone H”
2021 / Nature Communications
De novo designed self-assembling peptides (SAPs) are promising building blocks of supramolecular biomaterials, which can fulfill a wide range of …
Continue reading “Intracellular artificial supramolecules based on de novo designed Y15 peptides”
2021 / Nature Communications
α-Synuclein aggregation is a key driver of neurodegeneration in Parkinson’s disease and related syndromes. Accordingly, obtaining a molecule that targets …
2021 / Nature Communications
Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach …
Continue reading “Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex”
2021 / Scientific Report
Antimicrobial peptides (AMPs) have emerged as a promising alternative to small molecule antibiotics. Although AMPs have previously been isolated in …
2021 / Scientific Report
Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new …
Continue reading “Curcubinoyl flavonoids from wild ginseng adventitious root cultures”
2021 / Scientific Report
Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly …
