Peak decay analysis and biointeraction studies of immunoglobulin binding and dissociation on protein G affinity microcolumns

2018 / Methods, Volume 146, 15 August 2018, Pages 39-45

Protein G can be a valuable binding agent for antibodies and immunoglobulins in methods such as immunosensors, chromatographic-based immunoassays, and …

Heather Haffner

Identification of GXXXXG motif in Chrysophsin-1 and its implication in the design of analogs with cell-selective antimicrobial and anti-endotoxin activities

2017 / Scientific Reports

Marine fish antimicrobial peptide, chrysophsin-1 possesses versatile biological activities but its non-selective nature restricts its therapeutic possibilities. Often small alterations …

Leah Pandiscia, PhD

Multispectroscopic and bioimaging approach for the interaction of rhodamine 6G capped gold nanoparticles with bovine serum albumin

2018 / Journal of Photochemistry and Photobiology B: Biology

Binding interaction of Bovine Serum Albumin (BSA) with newly prepared rhodamine 6G-capped gold nanoparticles (Rh6G-Au NPs) under physiological conditions (pH 7.2) …

Leah Pandiscia, PhD

The First Five‐Membered‐Heterocycle‐Fused Subphthalocyanine Analogues: Chiral Tri(benzo[b]thiopheno)subporphyrazines

2014 / Chemistry A European Journal

Two tri(benzo[b]thiopheno)subporphyrazine regioisomers with C3 and C1 molecular symmetry have been isolated from the cyclotrimerization of benzo[b]thiophene‐2,3‐dicarbonitrile as the first five‐membered‐heterocycle‐fused subphthalocyanine analogues. Optical …

Leah Pandiscia, PhD

Biophysical and structural characterization of the putative nickel chaperone CooT from Carboxydothermus hydrogenoformans

2018 / Journal of Biological Inorganic Chemistry

Carboxydothermus hydrogenoformans is a model microorganism for the study of [NiFe]–CODH, a key enzyme of carbon cycle in anaerobic microorganisms. The enzyme …

Leah Pandiscia, PhD

Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase

2018 / International Journal of Biological Macromolecules

Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein kinase, plays a major role in the oncogenesis and tumour progression. The conformational stability and unfolding …

Leah Pandiscia, PhD

Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum

2015 / PLoS ONE

Thermoplasma acidophilum is a thermophilic archaeon that uses both non-phosphorylative Entner-Doudoroff (ED) pathway and Embden-Meyerhof-Parnas (EMP) pathway for glucose degradation. While …

Leah Pandiscia, PhD

Immunochemical Approach for Monitoring of Structural Transition of ApoA-I upon HDL Formation Using Novel Monoclonal Antibodies

2017 / Scientific Reports

Apolipoprotein A-I (apoA-I) undergoes a large conformational reorganization during remodeling of high-density lipoprotein (HDL) particles. To detect structural transition of …

Leah Pandiscia, PhD