A computationally designed peptide derived from Escherichia colias a potential drug template for antibacterial and antibiofilm therapies

2018 / ACS Infectious Diseases

Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we …

Leah Pandiscia, PhD

Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria in Submicromolar Concentration

2018 / Bioconjugate Chemistry

Synthetic antibacterial peptides are advanced weapons that scientists design and produce facing current treats due to harmful and mortal pathogens, …

Leah Pandiscia, PhD

Geometrical Changes in the Hemes of Bacterial Surface c-type Cytochromes Reveal Flexibility in their Binding Affinity with Minerals

2018 / Langmuir

Microbial extracellular electron transport occurs via the physical and electrical association of outer-membrane c-type cytochromes (OM c-Cyts) with extracellular solid …

Leah Pandiscia, PhD

Cooperative Metal–Ligand Influence on the Formation of Coordination Polymers, Conducting and Photophysical Properties of Tl(I) β-oxodithioester Complexes

2018 / Dalton Transactions

Eight novel Tl(I) β-oxodithioester complexes, [TlL]n (1–8) with ligands, L = methyl-3-hydroxy-3-(2-furyl)-2-propenedithioate (L1), methyl-3-hydroxy-3-(2-thienyl)-2-propenedithioate (L2), methyl-3-hydroxy-3-(3-pyridyl)-2-propenedithioate (L3), methyl-3-hydroxy-3-(4-pyridyl)-2-propenedithioate (L4), methyl-3-hydroxy-3-(9-anthracenyl)-2-propenedithioate …

Leah Pandiscia, PhD

Atropisomeric meroterpenoids with rare triketone-phloroglucinol-terpene hybrids from Baeckea frutescens

2018 / Organic & Biomolecular Chemistry

Baefrutones A–F (1–6), six new meroterpenoids with rare triketone-phloroglucinol-monoterpene/sesquiterpene frameworks, together with their biosynthetically related intermediate (±)-baeckenon B (7), were …

Leah Pandiscia, PhD

Amyloid aggregation of Bacillus circulans xylanase under a native condition and its modulation by beta‐amyloid‐derived peptide fragments

2018 / ChemBioChem

Aggregation of intrinsically disordered proteins into fibrils is implicated in many neurodegenerative diseases. Amyloid aggregation is a generic property of …

Leah Pandiscia, PhD

A comprehensive calorimetric, spectroscopic, and molecular docking investigation to probe the interaction of colchicine with HEWL

2018 / Journal of Thermal Analysis and Calorimetry

Colchicine (Col), a naturally occurring alkaloid, has been used as an anti-inflammatory, anti-fibrotic, and anti-tumor drug. The present study reports …

Leah Pandiscia, PhD