Enantiomeric impurity analysis using circular dichroism spectroscopy with United States Pharmacopeia liquid chromatographic methods

2018 / Journal of Pharmaceutical and Biomedical Analysis

Over 300 chiral drug substances lack official United States Pharmacopeia (USP) methods for the enantiomeric purity determination. Because enantiomeric analysis …

Leah Pandiscia, PhD

DNA groove‐binding ability of luminescent platinum(II) complexes based on a family of tridentate N^N^C ligands bearing differently substituted alkyl tethers

2018 / Journal of Inorganic and General Chemistry

A family of luminescent Pt(II) complexes is presented capable of binding DNA duplexes via groove binding. The complexes are based …

Leah Pandiscia, PhD

Synthesis, characterization, aggregation-induced emission, solvatochromism and mechanochromism of fluorinated benzothiadiazole bonded to tetraphenylethenes

2018 / RSC Advances

Compounds consisting of unsubstituted, monofluoro and difluoro substituted benzothiadiazole bonded to two tetraphenylethenes were successfully prepared by palladium catalyzed Suzuki–Miyaura …

Leah Pandiscia, PhD

Nonplanar Macrocycle Consisting of Four Pyridine and Phenol Units Connected with Acetylene Bonds Displaying Preferential Binding to Maltoside over Monosaccharides

2018 / The Journal of Organic Chemistry

A nonplanar macrocycle consisting of four pyridine–acetylene–phenol units was developed as a host for saccharide guest molecules. The macrocycle was …

Leah Pandiscia, PhD

Aggregation‐induced emission enhancement of anthracene‐derived Schiff base compounds and their application as a sensor for bovine serum albumin and optical cell imaging

2018 / Luminescence

Three anthracene‐based Schiff base complexes, R1–R3 (R1 = (E)‐N´‐((anthracen‐10‐yl)methylene)benzohydrazide; R2 = (E)‐1‐((anthracen‐10‐yl)methylene)‐4‐phenylsemicarbazide; and R3 = (E)‐1‐((anthracen‐10‐yl)methylene)‐4‐phenylthiosemicarbazide) were synthesized from 9‐anthracenecarboxaldehyde, benzohydrazide, 4‐phenylsemicarbazide and 4‐phenylthiosemi‐carbazide respectively, and characterized …

Leah Pandiscia, PhD

Benzothiazole-Based AIEgen with Tunable Excited-State Intramolecular Proton Transfer and Restricted Intramolecular Rotation Processes for Highly Sensitive Physiological pH Sensing

2018 / ACS Sensors

In this work, a benzothiazole-based aggregation-induced emission luminogen (AIEgen) of 2-(5-(4-carboxyphenyl)-2-hydroxyphenyl)benzothiazole (3) was designed and synthesized, which exhibited multifluorescence emissions …

Leah Pandiscia, PhD

Unconventional Three-Armed Luminogens Exhibiting Both Aggregation-Induced Emission and Thermally Activated Delayed Fluorescence Resulting in High-Performing Solution-Processed Organic Light-Emitting Diodes

2018 / ACS Applied Material & Interfaces

In this work, three-armed luminogens IAcTr-out and IAcTr-in were synthesized and used as emitters bearing triazine and indenoacridine moieties in thermally activated delayed fluorescence …

Leah Pandiscia, PhD

Pyrochlore Ce2Zr2O7 decorated over rGO: a photocatalyst that proves to be efficient towards the reduction of 4-nitrophenol and degradation of ciprofloxacin under visible light

2018 / Physical Chemistry Chemical Physics

In the present study, a series of Ce2Zr2O7@rGO nanocomposites were synthesized using a simple solution combustion method followed by a …

Leah Pandiscia, PhD

Flexible versus rigid G‐quadruplex DNA ligands ‐ synthesis of two series of bis‐indole derivatives and comparison of their interactions with G‐quadruplex DNA.

2018 / Chemistry A European Journal

Small molecules that target G‐quadruplex (G4) DNA structures are not only valuable to study G4 biology but also for their …

Leah Pandiscia, PhD