A novel adduct of ECG fused to piceid and four new dimeric stilbene glycosides from Polygonum cuspidatum

By Ya-nan Yang, Fu-shuang Li, Fu Liu, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang

July 28, 2017

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Title

A novel adduct of ECG fused to piceid and four new dimeric stilbene glycosides from Polygonum cuspidatum

Author

Ya-nan Yang, Fu-shuang Li, Fu Liu, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang

Year

2016

Journal

RSC Advances

Abstract

Polyflavanostilbene B (1), an unusual adduct of epicatechin-3-O-gallate fused to piceid through a carbon–carbon bond, four new dimeric stilbene glycosides (2–5), three new stilbene glucosides (6–8), one new flavan glucoside (9), and six known compounds were isolated from the rhizome ofPolygonum cuspidatum. The structures of these compounds were elucidated using spectroscopic data, including electronic circular dichroism (ECD) and Rh2(OCOCF3)4-induced CD spectra. All of the compounds were screened for their inhibitory activity against α-glucosidase using acarbose as a positive control (IC50 = 385 μM), and strong inhibitory activity against α-glucosidase was observed for compound 8 (IC50 = 3.04 μM).

Full Article

http://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra11135a

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Medicinal