Title
Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
Author
Lie-Chwen Lin, Ling-Ling Yang, Cheng-Jen Chou
Year
2003
Journal
Phytochemistry
Abstract
Two plumbagic acid glucosides, 3′-O-β-glucopyranosyl plumbagic acid and 3′-O-β-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
Instrument
J-715
Keywords
Circular dichroism, Stereochemistry, Natural products, Medicinal