Title
Anti-HIV-1 activities of constituents from the rhizomes of Boesenbergia thorelii
Author
Wisuwat Thongphichai, Patoomratana Tuchinda, Manat Pohmakotr, Vichai Reutrakul, Radeekorn Akkarawongsapat, Chanita Napaswad, Jitra Limthongkul, Thaya Jenjittikul, Saowanit Saithong
Year
2019
Journal
Fitoterpia
Abstract
A new lignan, thoreliin A (1), and a new bisnorlignan, thoreliin B (2), were isolated from a MeOH extract of the rhizomes of Boesenbergia thorelii. In addition, the known bisnorlignans 3 and 4, neolignan 5, phenylpropanoids 6–15, as well as benzenoids 18–21 were also obtained from the same source. The structures were elucidated based on their spectroscopic data. By single crystal X-ray analysis, the relative stereochemistry of 1 was confirmed. All isolated compounds were evaluated for anti-HIV-1 activities. Among them, thoreliin A (1) exhibited anti-HIV-1 activities on both HIV-1 reverse transcriptase (41.43% inhibition at 200 μg/mL) and syncytium reduction assays (EC50 20.6 μM, SI 3.7), while compounds 3–6, 9 and 11–21 showed anti-HIV-1 activity only in the anti-syncytium assay (EC50 6.6–454.1 μM, SI >1.32–7.75).
Instrument
V-530, J-810
Keywords
Absorption, Circular dichroism, Stereochemistry, Absolute configuration, Agriculture and environmental, Medicinal