Synthesis of some novel substituted phenylisoxazol phenoxy 2-methylpropanoic acids and there in vivo hypolipidemic activity

By Santosh N. Mokale, Pritam N. Dube, Manjusha C. Nevase, Nikhil S. Sakle, Vishakha R. Shelke, Swati A. Bhavale & Afreen Begum

April 23, 2020

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Title

Synthesis of some novel substituted phenylisoxazol phenoxy 2-methylpropanoic acids and there in vivo hypolipidemic activity

Author

Santosh N. Mokale, Pritam N. Dube, Manjusha C. Nevase, Nikhil S. Sakle, Vishakha R. Shelke, Swati A. Bhavale & Afreen Begum

Year

2016

Journal

Medicinal Chemistry Research

Abstract

The novel series of phenylisoxazol phenoxy 2-methylpropanoic acid derivatives were synthesized and evaluated for their in vivo hypolipidemic activity by triton WR-1339-induced hyperlipidemia in rats. The newly synthesized compounds 5a and 5i showed significant decrease in the serum TCH, TG, LDL and VLDL along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index, TC:HDL risk ratios compared to cholesterol-induced hyperlipidemic control group. These molecules indeed have the potential to be developed as antihypolipidemic molecules.

Full Article

https://link.springer.com/article/10.1007/s00044-015-1498-2

Instrument

HPLC

Keywords

HPLC, Hyperlipidemia, Phenoxy propanoic acid, Isoxazole, Atherogenic index