Three new sesquiterpenoids from agarwood of Aquilaria crassna

July 28, 2017

Title

Three new sesquiterpenoids from agarwood of Aquilaria crassna

Author

Hong-Ni Wang, Wen-Hua Dong, Sheng-Zhuo Huang, Wei Li, Fan-Dong Kong, Hao Wang, Jun Wang, Wen-Li Mei, Hao-Fu Dai

Year

2016

Journal

Fitoterapia

Abstract

Three new sesquiterpenoids (1–3), together with two known ones were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna. The new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, 1D and 2D NMR). Compounds 1–5 were isolated from agarwood of A. crassna for the first time. In the acetylcholinesterase inhibition experiment of 2–5, compound 3 showed acetylcholinesterase inhibition activity (IR 42.9 ± 0.6%). Compound 5 expressed antibacterial activities against Staphylococcus aureus and Ralstonia solanacearum with diameter of the inhibition zones of 12.35 ± 0.11 mm and 16.90 ± 0.09 mm, respectively.

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Agricultural and environmental, Natural products