Vibrational Circular Dichroism System Equipped with Quantum Cascade Laser for Microscopic Scanning

August 18, 2021

Title

Vibrational Circular Dichroism System Equipped with Quantum Cascade Laser for Microscopic Scanning

Author

Hisako Sato, Masaru Shimizu, Keisuke Watanabe, Jun Yoshida, Izuru Kawamura, and Jun Koshoubu

Year

2021

Journal

Chemistry Letters, 2021, Vol.50, No.8

Abstract

A vibrational circular dichroism (VCD) system capable of microscopic scanning was developed. An intense infrared light from a quantum cascade laser was focused using two BaF2 lenses and passed through a pinhole of 0.1 mmϕ. A solid sample mounted on an automatic stage was scanned two-dimensionally with a spatial resolution of 100 µm in the wavenumber range of 1500–1740 cm−1. The feasibility of the system was validated by reproducing the authentic VCD peaks assigned to the amide I and II bands of a dipeptide, Gly-d-Leu.

Instrument

VCD

Keywords

VCD, microscopic scanning