FT-NIR microscope imaging for pharmaceutical tablet characterization

By Leah Pandiscia, PhD

Download PDF May 4, 2017

  • Industry

  • Technique

Introduction

The use of near-infrared (NIR) spectroscopy in the pharmaceutical industry has grown rapidly in the past decade. The IMV-4000 Infrared Linear Array Microscope with an FT/IR-4000 or FT/IR-6000 instrument with NIR spectral range offers rapid imaging of pharmaceutical tablets, a valuable tool in the quality control of tablet properties, offering measurement data with high specificity and sensitivity. The data can be used with Principal Component Analysis (PCA) chemometric software for the evaluation of component distribution and contaminant identification.

Instrument:FTIR-6200 with IMV-4000 CaF2 beam splitter, NIR source, etc.
Sample:Antimotion-sickness drug
Measurement Mode:Reflectance mode
Measurement Area:10 mm x 10 mm
Measurement Points:100 x 100
Accumulation:64 scans
Peak height (1935 nm)
PCA mapping
Sample

About the Author

Leah Pandiscia received her PhD from Drexel University where she studied Biophysical Chemistry. She is a Spectroscopy Applications Scientist at JASCO.