KnowledgeBase Articles Archive

Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) Nanoparticles in Water: Interblock van der Waals Attraction Opposes Amphiphilic Phase Separation

2019 / Macromolecules

Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) diblock copolymers comprise two miscible blocks: the hydrophilic and thermosensitive PiPOx and the hydrophobic PLA, a biocompatible and… Continue reading Poly(2-isopropyl-2-oxazoline)-b-poly(lactide) (PiPOx-b-PLA) Nanoparticles in Water: Interblock van der Waals Attraction Opposes Amphiphilic Phase Separation

Unprecedented Behavior of (9R)-9-Hydroxystearic Acid-Loaded Keratin Nanoparticles on Cancer Cell Cycle

2019 / Molecular Pharmaceutics

Histone deacetylases, HDACs, have been demonstrated to play a critical role in epigenetic signaling and were found to be overexpressed… Continue reading Unprecedented Behavior of (9R)-9-Hydroxystearic Acid-Loaded Keratin Nanoparticles on Cancer Cell Cycle

Unwinding a spiral of cellulose nanocrystals for stimuli-responsive stretchable optics

2019 / Nature Communications

Cellulose nanocrystals (CNCs) derived from biomass spontaneously organize into a helical arrangement, termed a chiral nematic structure. This structure mimics… Continue reading Unwinding a spiral of cellulose nanocrystals for stimuli-responsive stretchable optics

Systematic investigation of sequence requirements for DNA i-motif formation

2019 / Nucleic Acids Research

The formation of intercalated motifs (iMs) — secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is… Continue reading Systematic investigation of sequence requirements for DNA i-motif formation

Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin

2019 / International Journal of Molecular Sciences

Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can… Continue reading Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin

Expression, purification and characterization of the dimeric protruding domain of Macrobrachium rosenbergii nodavirus capsid protein expressed in Escherichia coli

2019 / PLoS ONE

Macrobrachium rosenbergii nodavirus (MrNV) is the causative agent of white tail disease (WTD) which seriously impedes the production of the giant… Continue reading Expression, purification and characterization of the dimeric protruding domain of Macrobrachium rosenbergii nodavirus capsid protein expressed in Escherichia coli

Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State

2019 / antioxidants

Peroxiredoxins(Prdx), the family of non-selenium glutathione peroxidases, are important antioxidant enzymes that defend our system from the toxic reactive oxygen… Continue reading Hyperoxidation of Peroxiredoxin 6 Induces Alteration from Dimeric to Oligomeric State

Scalable, Non-denaturing Purification of Phosphoproteins Using Ga3+-IMAC: N2A and M1M2 Titin Components as Study case

2019 / The Protein Journal

The purification of phosphorylated proteins in a folded state and in large enough quantity for biochemical or biophysical analysis remains… Continue reading Scalable, Non-denaturing Purification of Phosphoproteins Using Ga3+-IMAC: N2A and M1M2 Titin Components as Study case

Chiral Self-Sorting Process with Ditopic Ligands: Alternate or Block Metallopolymer Assembly as a Function of the Metal Ion

2019 / ACS Omega

We report an extensive study on the coordination behavior of chiral ditopic bridging ligands, which lead to metallosupramolecular polymers in… Continue reading Chiral Self-Sorting Process with Ditopic Ligands: Alternate or Block Metallopolymer Assembly as a Function of the Metal Ion

Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers

2019 / Scientific Reports

Foldamers, which are folded oligomers with well-defined conformations, have been recently reported to have a good cell-penetrating ability. α,α-Disubstituted α-amino… Continue reading Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers

Postsynthetic Covalent and Coordination Functionalization of Rhodium(II)-Based Metal–Organic Polyhedra

2019 / JACS

Metal–organic polyhedra (MOP) are ultrasmall (typically 1–4 nm) porous coordination cages made from the self-assembly of metal ions and organic… Continue reading Postsynthetic Covalent and Coordination Functionalization of Rhodium(II)-Based Metal–Organic Polyhedra

Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity

2019 / Journal of Natural Products

Three new compounds, namely, 4-(4′-hydroxy-3′-methoxyphenyl)-3,5,7-trihydroxycoumarin (1) and sulawesins A (2) and B (3), were isolated from the propolis of stingless… Continue reading Propolis Components from Stingless Bees Collected on South Sulawesi, Indonesia, and Their Xanthine Oxidase Inhibitory Activity

Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions

2019 / Biochemistry

Amyloids are polypeptide supramolecular assemblies that have been historically associated with numerous pathologies. Nonetheless, recent studies have identified many amyloid… Continue reading Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions

Enhancement of protein stability by an additional disulfide bond designed in human neuroglobin

2019 / RSC Advances

Human neuroglobin (Ngb) forms an intramolecular disulfide bond between Cys46 and Cys55, with a third Cys120 near the protein surface,… Continue reading Enhancement of protein stability by an additional disulfide bond designed in human neuroglobin

Characterization and Expression Profiling of Recombinant Parathyroid Hormone (rhPTH) Analog 1–34 in Escherichia coli, Precise with Enhanced Biological Activity

2019 / International Journal of Peptide Research and Therapeutics

Human truncated parathyroid hormone [hPTH (1–34)], a peptide hormone which accelerated the research interest towards the theraputical applications. This study… Continue reading Characterization and Expression Profiling of Recombinant Parathyroid Hormone (rhPTH) Analog 1–34 in Escherichia coli, Precise with Enhanced Biological Activity

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

2019 / Redox Biology

The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. The mechanisms underlying the… Continue reading Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

Low-resolution structure, oligomerization and its role on the enzymatic activity of a sucrose-6-phosphate hydrolase from Bacillus licheniformis

2019 / Amino Acids

Knowing the key features of the structure and the biochemistry of proteins is crucial to improving enzymes of industrial interest… Continue reading Low-resolution structure, oligomerization and its role on the enzymatic activity of a sucrose-6-phosphate hydrolase from Bacillus licheniformis

Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation

2019 / Advanced Functional Materials

Surface nanotopograpy has been recognized as an important regulator of cellular responses including those of immune cells, the latter being… Continue reading Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation

Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers

2019 / Biomolecules

The interaction of neuropeptides, vasoactive intestinal peptide (VIP), or growth hormone-releasing hormone (GHRH), with a cationic carbosilane dendrimer forms dendriplexes… Continue reading Anticancer Activity of Dendriplexes against Advanced Prostate Cancer from Protumoral Peptides and Cationic Carbosilane Dendrimers

Spreading Films of Anthracene-Containing Gelator Molecules at the Air/Water Interface: Nanorod and Circularly Polarized Luminescence

2019 / Langmuir

Two enantiomeric gelator molecules containing anthracene moiety were assembled at the air/water interface and several new insights into the films… Continue reading Spreading Films of Anthracene-Containing Gelator Molecules at the Air/Water Interface: Nanorod and Circularly Polarized Luminescence

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