KnowledgeBase Articles Archive

Search for Shorter Portions of the Proline‐Rich Antimicrobial Peptide Fragment Bac5(1–25) That Retain Antimicrobial Activity by Blocking Protein Synthesis

2019 / ChemMedChem

The spread of antibiotic‐resistant pathogens has boosted the search for new antimicrobial drugs. Proline‐rich antimicrobial peptides are promising lead compounds… Continue reading Search for Shorter Portions of the Proline‐Rich Antimicrobial Peptide Fragment Bac5(1–25) That Retain Antimicrobial Activity by Blocking Protein Synthesis

Bis‐Lactam Peptide [i, i + 4]‐Stapling

2019 / Chinese Journal of Chemistry

Even though the bis‐lactam peptide stapling with the [i, i + 7] and the [i, i + 11] systems has been known to be… Continue reading Bis‐Lactam Peptide [i, i + 4]‐Stapling

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

2019 / PLoS biology

All animal cells use the motor cytoplasmic dynein 1 (dynein) to transport diverse cargo toward microtubule minus ends and to… Continue reading A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

2019 / Scientific Reports

Characterization of small oligomers formed at an early stage of amyloid formation is critical to understanding molecular mechanism of pathogenic… Continue reading Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

Effect of tyrosinase‐catalyzed crosslinking on the structure and allergenicity of turbot parvalbumin mediated by caffeic acid

2019 / Journal of the Science of Food and Agriculture

Enzymatic treatment of allergenic protein can alter their functional properties at a mild reaction condition due to specificity of enzymes.… Continue reading Effect of tyrosinase‐catalyzed crosslinking on the structure and allergenicity of turbot parvalbumin mediated by caffeic acid

Purification and Characterization of a Cadmium-Binding Protein from Lentinula edodes

2019 / Journal of Agricultural and Food Chemistry

Many organisms possess the ability to produce metal-binding proteins to absorb cadmium. Metallothioneins, an important family of cysteine-rich metal-binding proteins,… Continue reading Purification and Characterization of a Cadmium-Binding Protein from Lentinula edodes

In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

2019 / ACS Nano

Peptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale… Continue reading In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters

2019 / Microchimica Acta

A fluorogenic probe has been developed for determination of telomerase activity using chimeric DNA-templated silver nanoclusters (AgNCs). The formation of… Continue reading Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters

Tuning the Handedness: Role of Chiral Component in Peptide-Appended Bolaamphiphile-Based Coassembled Hydrogels

2019 / Langmuir

Chirality is the intrinsic property of a molecule that can be tuned by the change in chirality of a molecule… Continue reading Tuning the Handedness: Role of Chiral Component in Peptide-Appended Bolaamphiphile-Based Coassembled Hydrogels

Self-Assembly of Antimitotic Peptide at Membranes: Computational and Experimental Investigation

2019 / ACS Omega

We report the assembly behavior of an antimitotic cell penetrating peptide (CPP) bound with membrane and in solution using experimental… Continue reading Self-Assembly of Antimitotic Peptide at Membranes: Computational and Experimental Investigation

Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1

2018 / Marine Drugs

Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a… Continue reading Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1

Enantiomers of Single Chirality Nanotube as Chiral Recognition Interface for Enhanced Electrochemical Chiral Analysis

2019 / analytical chemistry

Although separation of single-walled carbon nanotubes (SWCNTs) according to their helicity and handedness has been attracting tremendous interest recently, exploration… Continue reading Enantiomers of Single Chirality Nanotube as Chiral Recognition Interface for Enhanced Electrochemical Chiral Analysis

Slow Motion Protein Dance Visualized Using Red-Edge Excitation Shift of a Buried Fluorophore

2019 / The Journal of Physical Chemistry B

It has been extremely challenging to detect protein structures with a dynamic core, such as dry molten globules, that remain… Continue reading Slow Motion Protein Dance Visualized Using Red-Edge Excitation Shift of a Buried Fluorophore

Relationship between molecular structures of uniquely designed C2-symmetric axially chiral dopants and their helical twisting properties in cholesteric liquid crystals

2019 / Journal of Materials Chemistry C

The induction of chirality in a liquid crystal (LC) can lead to the development of functional LC materials with enhanced… Continue reading Relationship between molecular structures of uniquely designed C2-symmetric axially chiral dopants and their helical twisting properties in cholesteric liquid crystals

Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

2019 / Organic Chemistry Frontiers

A pair of novel enantiomeric benzophenone-hemiterpene adducts, (+)-cytorhizophin A (1a) and (−)-cytorhizophin A (1b) as well as cytorhizophin B (2),… Continue reading Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae

Horseradish peroxidase-catalyzed hydrogelation consuming enzyme-produced hydrogen peroxide in the presence of reducing sugars

2019 / Soft Matter

In the present work, three kinds of reducing sugars: glucose, galactose, and mannose, are applied to horseradish peroxidase (HRP)-catalyzed hydrogelation… Continue reading Horseradish peroxidase-catalyzed hydrogelation consuming enzyme-produced hydrogen peroxide in the presence of reducing sugars

Computational design of symmetrical eight-bladed β-propeller proteins

2018 / IUCrJ

β-Propeller proteins form one of the largest families of protein structures, with a pseudo-symmetrical fold made up of subdomains called… Continue reading Computational design of symmetrical eight-bladed β-propeller proteins

Structure and Function Studies of Asian Corn Borer Ostrinia furnacalis Pheromone Binding Protein2

2018 / Scientific Reports

Lepidopteran male moths have an extraordinarily sensitive olfactory system that is capable of detecting and responding to minute amounts of… Continue reading Structure and Function Studies of Asian Corn Borer Ostrinia furnacalis Pheromone Binding Protein2

Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides

2019 / Biochemical and Biophysical Research Communications

d-amino acid-containing proteins have been found in several human tissues, and the spontaneous accumulation of d-amino acids in proteins is thought… Continue reading Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides

X-ray structure and characterization of a thermostable lipase from Geobacillus thermoleovorans