The abundant Plasmodium falciparum merozoite surface protein MSP2, a potential malaria vaccine candidate, is an intrinsically disordered protein with some nascent secondary… Continue reading Modulation of the aggregation of an amyloidogenic sequence by flanking-disordered region in the intrinsically disordered antigen merozoite surface protein 2
Leah Pandiscia, PhD
April 9, 2019
Leah Pandiscia, PhD
April 9, 2019
Synthesis of an entirely new series of arene ruthenium complexes [Ru(η6-C6H6)(L1)Cl]PF6, (1), [Ru(η6-C10H14)(L1)Cl]PF6 (2), [Ru(η6-C6H6)(L2)Cl]PF6 (3) and [Ru(η6-C10H14)(L2)Cl]PF6 (4) involving 5-[2-(1H-pyrazol-1-yl)quinoline]-BODIPY (L1) and… Continue reading Pyrazole appended quinoline-BODIPY based arene ruthenium complexes: their anticancer activity and potential applications in cellular imaging
Leah Pandiscia, PhD
April 9, 2019
This paper reports on synthesis, acid-base properties and self-structuring in water of chiral polyamidoamino acids (PAACs) obtained by polyaddition of N,N′-methylenebisacrylamide… Continue reading Self-Structuring in Water of Polyamidoamino Acids with Hydrophobic Side Chains Deriving from Natural α-Amino Acids
Leah Pandiscia, PhD
April 9, 2019
Diatoms show a special organisation of their plastid membranes, such that their thylakoidsspan the entire plastid in bands of three. While in higher plants… Continue reading Cation-dependent changes in the thylakoid membrane appression of the diatom Thalassiosira pseudonana
Leah Pandiscia, PhD
April 9, 2019
A series of novel poly(m-phenylene)s with terthiophene and/or chiral side chains have been developed to investigate the correlation between poly(m-phenylene)… Continue reading Synthesis, characterization, and self-assembly behavior of poly(m-phenylene)s with terthiophene and chiral side chains
Leah Pandiscia, PhD
April 9, 2019
Crytotanshinone (CTSO) is a Chinese herbal medicine active ingredient isolated from Salvia miltiorrhiza. In this work, the interaction of CTSO… Continue reading Structural and Thermodynamic Investigation into the Protein-Binding Properties of a Natural Product Crytotanshinone
Leah Pandiscia, PhD
April 9, 2019
Templating methods, combined with colloidal chemistry synthesis, provide a strategy to fabricate inorganic nanomaterials with controllable architectures. Computationally designed peptide… Continue reading Fabrication of One- and Two-Dimensional Gold Nanoparticle Arrays on Computationally Designed Self-Assembled Peptide Templates
Leah Pandiscia, PhD
April 9, 2019
Investigation into the interactions between biomolecules DNA/RNA and carbon nanomaterials is very important for applications in bioassays and bioanalysis. Graphene… Continue reading Reduced Graphene Oxide-Oligonucleotide Interfaces: Understanding Based on Electrochemical Oxidation of Guanines
Leah Pandiscia, PhD
April 9, 2019
R‐ω‐Transaminases (RTAs) catalyse the conversion of R‐configured amines [e.g., (R)‐1‐phenylethylamine] into the corresponding ketones (e.g., acetophenone), by transferring an amino group… Continue reading Covalent Linkage of an R‐ω‐Transaminase to a d‐Amino Acid Oxidase through Protein Splicing to Enhance Enzymatic Catalysis of Transamination
Leah Pandiscia, PhD
April 9, 2019
This paper discusses multi‐spectroscopic and molecular docking analysis of the interaction between atenolol (ATN) and deoxyribose nucleic acid (DNA) using… Continue reading Comprehensive analysis of the atenolol – DNA complex by viscometric, molecular docking and spectroscopic techniques
Leah Pandiscia, PhD
April 9, 2019
We have reported the eco-friendly gold nanoparticles (AuNPs) from 15% aqueous leaf extract of therapeutic plant Nymphaea nouchali where leaf extract acts as both… Continue reading Spectroscopic study on interaction of Nymphaea nouchali leaf extract mediated bactericidal gold nanoparticles with human serum albumin
Leah Pandiscia, PhD
April 9, 2019
Increasing drug resistance in pathogens including Mycobacterium tuberculosis (MTB) has been ascribed to mutations in the known target genes. However, many of… Continue reading Ethambutol targets the glutamate racemase of Mycobacterium tuberculosis—an enzyme involved in peptidoglycan biosynthesis
Leah Pandiscia, PhD
April 9, 2019
Self-assembly of peptides and amyloid fibrils offers an appealing approach for creating chiral nanostructures, which has promising applications in the… Continue reading Aromatic Motifs Dictate Nanohelix Handedness of Tripeptides
Leah Pandiscia, PhD
April 9, 2019
In nontypeable Haemophilus influenzae (NTHi), the oligopeptide-binding protein (OppA) serves as the substrate-binding protein (SBP) of the oligopeptide transport system responsible for… Continue reading Oligopeptide-binding protein from nontypeable Haemophilus influenzae has ligand-specific sites to accommodate peptides and heme in the binding pocket
Leah Pandiscia, PhD
April 9, 2019
Single molecular changes on a tripeptide can have dramatic effects on their self-assembly and hydrogelation. Herein, we explore C-terminal residue variation… Continue reading C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs
Leah Pandiscia, PhD
April 9, 2019
Two fluorescent aptasensor methods were developed for the detection of ATP in biochemical systems. The first method consisted of a… Continue reading Comparison of turn-on and ratiometric fluorescent G-quadruplex aptasensor approaches for the detection of ATP
Leah Pandiscia, PhD
April 9, 2019
New luminescent Pt(II) complexes with the chiral counter anions [PtCl(tpy)](L‐Hta) (1‐L) and [PtCl(tpy)](DL‐Hta) (1‐DL; tpy = 2,2’:6’,2’’‐terpyridine; L‐H2ta = L‐tartaric… Continue reading Effect of the Chirality of Counter Anions on the Vapochromic Behavior of Luminescent Pt(II) Complexes
Leah Pandiscia, PhD
April 9, 2019
The amyloid precursor–like protein 2 (APLP2) molecule is a type I transmembrane protein that is crucial for survival, cell-cell adhesion,… Continue reading The crystal structure of amyloid precursor–like protein 2 E2 domain completes the amyloid precursor protein family
Leah Pandiscia, PhD
April 9, 2019
Two diketopyrrolopyrroles (DPP) and three rylenes (NDI, dPyr PDI, and dEO PDI) were combined to form six hierarchical superstructures that… Continue reading Singlet Fission in Combinatorial Diketopyrrolopyrrole—Rylene Supramolecular Films
Leah Pandiscia, PhD
April 9, 2019
