Found 9617 Results / Page 194 of 481
2019 / Organic & Biomolecular Chemistry
To systematically determine the effect of N2-heteroaryl modification on the stability of G-quadruplex structures, six types of N2-heteroarylated deoxyguanosines were… Continue reading Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex
2019 / Journal of Agricultural and Food Chemistry
Novel Gemini dodecyl O-glucoside-based primary, secondary, and tertiary vesicles were developed in this work utilizing layer-by-layer deposition of polysaccharides (e.g., sodium… Continue reading Interaction between Gemini Dodecyl O-Glucosides-Based Multilayer Vesicles and β-Lactoglobulin: The Dominant Role of Surface Charge
2019 / ACS Chemical Neuroscience
Six alpha-Synuclein point mutations are currently known to be associated with familial par-kinsonism: A30P, E46K, H50Q, G51D, A53E and A53T.… Continue reading Different effects of alpha-Synuclein mutants on lipid binding and aggregation detected by single molecule fluorescence spectroscopy and ThT fluorescence-based measurements
2019 / bioRxiv
Cell division by meiosis involves an extraordinary chromosome choreography including pairing, synapsis and crossing over between homologous chromosomes. The many… Continue reading A pseudo-meiotic centrosomal function of TEX12 in cancer
2019 / Chromosoma
The reduction in chromosome number during meiosis is essential for the production of haploid germ cells and thereby fertility. To… Continue reading Molecular structure of human synaptonemal complex protein SYCE1
2018 / Science Advances
Stereochemistry is vital for pharmaceutical development and can determine drug efficacy. Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as… Continue reading Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide
2018 / Science Advances
In every established species, protein-protein interactions have evolved such that they are fit for purpose. However, the molecular details of… Continue reading Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
2018 / Science Advances
Bent-core liquid crystal (LC) molecules are known to form mesophases with fascinating polar order and supramolecular chirality despite the achiral… Continue reading Phase behaviors of colloidal analogs of bent-core liquid crystals
2019 / Journal of Medicinal Chemistry
RE31 is a 31-nt DNA aptamer, consisting of the G quadruplex and a duplex domain, which is able to effectively… Continue reading Improved RE31 analogues containing modified nucleic acid monomers: thermodynamic, structural and biological effects
2019 / Luminescence
Maltol, a food additive, is extensively used in our daily life. To date, its biological safety is still debated. In… Continue reading Spectroscopic characterization, calorimetric study and molecular docking to evaluate the bioconjugation of maltol with hemoglobin
2019 / Journal of Molecular Biology
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTD) are incurable motor neuron diseases associated with muscle weakness, paralysis and… Continue reading RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43
2019 / Polymers
: Newly synthesized two kinds of achiral phenylacetylenes having a free-base- or a zinc-porphyrin (1 and Zn1, respectively) were polymerized by using a… Continue reading Helix-Sense-Selective Polymerization of Phenylacetylenes Having a Porphyrin and a Zinc-Porphyrin Group: One-Handed Helical Arrangement of Porphyrin Pendants
2019 / Langmuir
Chiral nanostructures exhibited distinctive functions and attractive application in complex biological systems, which demonstrated the subject of many outstanding researches.… Continue reading Chiral Nanostructured Composite Films via Solvent-Tuned Self-Assembly and Their Enantioselective Performances
2019 / Scientific Reports
Der p 2 is a major dust mite allergen and >80% of mite allergic individuals have specifc IgE to this… Continue reading The major allergen Der p 2 is a cholesterol binding protein
2019 / ChemBioChem
Antimicrobial peptides (AMPs) kill bacteria by targeting their membranes via various mechanisms involving peptide assembly often coupled with disorder‐to‐order structural… Continue reading Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 by the Polysulfonated Drug Suramin: A Step Closer to in vivo Complexity
2018 / Scientific Reports
Bromo-Noscapine (BrNs) is a tubulin-binding cytotoxic agent with significant activity against breast and lung cancer. The mechanistic interaction insight into… Continue reading Mechanistic Interaction Study of Bromo-Noscapine with Bovine Serum Albumin employing Spectroscopic and Chemoinformatics Approaches
2018 / Inorganic Chemistry
Zinc ion binding is a principal event in the achievement of the correct fold in classical zinc finger domains since… Continue reading Ni(II), Hg(II), and Pb(II) Coordination in the Prokaryotic Zinc-Finger Ros87
2018 / Bioorganic & Medicinal Chemistry
Two new sesquiterpene-based analogues, namely harzianoic acids A (1) and B (2), were isolated from a sponge-associated fungus Trichoderma harzianum. Their… Continue reading Harzianoic acids A and B, new natural scaffolds with inhibitory effects against hepatitis C virus
2018 / Journal of Natural Products
Five new water-soluble amido- and aminoanthraquinone pigments, hypalocrinins A–E (1–5), the new amidoanthraquinone biaryls hypalocrinin F (6) and hypalocrinin G… Continue reading Hypalocrinins, Taurine-Conjugated Anthraquinone and Biaryl Pigments from the Deep Sea Crinoid Hypalocrinus naresianus
2019 / antioxidants
Members of the DJ-1 protein family are multifunctional enzymes whose loss increases the susceptibility of the cell to oxidative stress.… Continue reading Bifunctional Chloroplastic DJ-1B from Arabidopsis thaliana is an Oxidation-Robust Holdase and a Glyoxalase Sensitive to H2O2
