Found 9617 Results / Page 196 of 481
2018 / BMC Research Notes
Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases, often referred as prion diseases. TSEs result from the… Continue reading Preparation of lyophilized recombinant prion protein for TSE diagnosis by RT-QuIC
2018 / Nature Communications
Polypeptides have broad applications and can be prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary amines,… Continue reading Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides
2018 / Soft Matter
The generally poor mechanical stability of hydrogels limits their use as functional materials for many biomedical applications. In this work,… Continue reading Poly(vinyl alcohol)-induced thixotropy of an L-carnosine-based cytocompatible, tripeptidic hydrogel
2019 / Food Packaging and Shelf Life
Fabrication of fish gelatin nanofilms was realized by electrospinning using low concentrations of acetic acid, malic acid and citric acid… Continue reading Study of electrospun fish gelatin nanofilms from benign organic acids as solvents
2018 / Scientific Reports
Cell death-inducing DFF45-like effect (CIDE) domain-containing proteins, DFF40, DFF45, CIDE-A, CIDE-B, and FSP27, play important roles in apoptotic DNA fragmentation… Continue reading Crystal structure and mutation analysis revealed that DREP2 CIDE forms a filament-like structure with features differing from those of DREP4 CIDE
2018 / BMC Technology
Proteins in inclusion bodies (IBs) present native-like secondary structures. However, chaotropic agents at denaturing concentrations, which are widely used for… Continue reading Association of high pressure and alkaline condition for solubilization of inclusion bodies and refolding of the NS1 protein from zika virus
2018 / The Journal of Organic Chemistry
As an effort to integrate natural products chemistry and coordination chemistry, a diastereomeric pair of chiral alkaloidal manifolds composed of… Continue reading Chiroptical Inversion of Europium(III) Complexes by Changing a Remote Stereogenic Center of a C2-Symmetric Bispyrrolidinoindoline Manifold
2018 / Allergy
Peanuts are most responsible for food‐induced anaphylaxis in adults in developed countries. An effective and safe immunotherapy is urgently needed.… Continue reading Chemically modified peanut extract shows increased safety while maintaining immunogenicity
2018 / IUBMB Life
Catechol‐O‐methyltransferase (COMT1) catalyzes the transfer of a methyl group from S‐adenosylmethionine (SAM) to various catechol substrates. COMTs play vital roles… Continue reading Functional and structural characterization of a novel catechol‐O‐methyltransferase from Schizosaccharomyces pombe
2018 / Nature Communications
Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different… Continue reading Dissymmetry enhancement in enantioselective synthesis of helical polydiacetylene by application of superchiral light
2018 / International Journal of Molecular Sciences
The synthetic peptide T11F (TCRVDHRGLTF), derived from the constant region of human IgM antibodies, proved to exert a significant activity… Continue reading Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide
2018 / The Journal of Organic Chemistry
Spiro polycyclic aromatic compounds have been known as rigid chiral scaffolds. In order to extend their applications, an efficient preparation… Continue reading [1]Benzothiophene-Fused Chiral Spiro Polycyclic Aromatic Compounds: Optical Resolution, Functionalization, and Optical Properties
2018 / JACS
Manipulating phase separation structures of thermo-responsive polymers will enhance the usefulness of structure-controllable materials in the fields such as drug… Continue reading Highly ordered polypeptide with UCST phase-separation behavior
2019 / Marine Drugs
Polysaccharide chromium (III) derivatives are gaining increasing attention in improving type 2 diabetes. In this study, the sulfated polysaccharide from Enteromorpha… Continue reading Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative
2019 / antioxidants
Thioredoxins (TRXs) are major protein disulfide reductases of the cell. Their redox activity relies on a conserved Trp-Cys-(Gly/Pro)-Pro-Cys active site… Continue reading Structural and Biochemical Insights into the Reactivity of Thioredoxin h1 from Chlamydomonas reinhardtii
2019 / European Biophysics Journal
Mercury (Hg) and lead (Pb) are known to be toxic non-radioactive elements, with well-described neurotoxicology. Much evidence supports the implication… Continue reading Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer’s disease
2018 / Journal of Biological Chemistry
Many intrinsically disordered proteins (IDPs) attain a well-defined structure in a coupled folding and binding reaction with another protein. Such… Continue reading A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins
2018 / JACS
Enzyme engineering tends to focus on the design of active sites for the chemical steps, while the physical steps of… Continue reading Molecular Gating of an Engineered Enzyme Captured in Real Time
2018 / analytical chemistry
Bioactive metal ions play important roles in both physiological and pathological processes. Developing biosensing probes for bioactive metal ion detection… Continue reading Dual-Aptamer-Conjugated Molecular Modulator for Detecting Bioactive Metal Ions and Inhibiting Metal-Mediated Protein Aggregation
2018 / Biochemistry
Multiple Sclerosis (MS) is an autoimmune disorder manifested via chronic inflammation, demyelination and neurodegeneration inside the central nervous system (CNS).… Continue reading Amyloid-like behavior of site-specifically citrullinated myelin oligodendrocyte protein (MOG) peptide fragments inside EBV infected B-cells influences their cytotoxicity and autoimmunogenicity.
