Found 9617 Results / Page 199 of 481
2019 / Bioorganic Chemistry
Alzheimer’s disease (AD) is a progressive neurodegenerative brain disease and is the most common cause of dementia in the elderly.… Continue reading A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation
2019 / Biomedicine & Pharmacotherapy
In order to improve the previously observed antichagasic activity of Cu(II) complexes containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis… Continue reading In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex
2018 / Human Reproduction
The plasma membrane integrity of peptide-treated sperm was assessed by cellular exclusion of Sytox Green, a membrane impermeable fluorescent DNA… Continue reading Antimicrobial peptide LL-37 and its truncated forms, GI-20 and GF-17, exert spermicidal effects and microbicidal activity against Neisseria gonorrhoeae
2018 / International Journal of Molecular Sciences
Stromal interaction molecule (STIM)-1 and -2 regulate agonist-induced and basal cytosolic calcium (Ca2+) levels after oligomerization and translocation to endoplasmic… Continue reading The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains
2018 / Journal of Structural Biology
Computational design with supersecondary structures as building blocks has proven effective in the construction of new proteins with controlled geometries.… Continue reading Asymmetric protein design from conserved supersecondary structures
2018 / polymers
Arginine-Glycine-Aspartate (RGD) tripeptide can promote cell adhesion when present in the amino acid of proteins such as fibronectin. In order… Continue reading An RGD-Containing Peptide Derived from Wild Silkworm Silk Fibroin Promotes Cell Adhesion and Spreading
2018 / Journal of Fluorescence
Mode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular… Continue reading Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative
2018 / RSC Advances
Chemoenzymatic polypeptide synthesis offers several advantages over chemical or other biological routes, however, the use of aqueous-based media suffers from… Continue reading Chemoenzymatic synthesis of polypeptides in neat 1,1,1,2-tetrafluoroethane solvent
2018 / Microbial Cell Factories
Increasing efforts have been made to assess the potential of Escherichia coli strains for the production of complex recombinant proteins.… Continue reading High level in vivo mucin-type glycosylation in Escherichia coli
2018 / Molecules
Amphibians´ skin produces a diverse array of antimicrobial peptides that play a crucial role as the first line of defense… Continue reading Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides
2018 / Applied Microbiology and Biotechnology
Fibroblast growth factor-21 (FGF-21) is a potential cytokine for type II diabetes mellitus. This study aimed to optimize recombinant human… Continue reading Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its anti-diabetic effects on ob/ob mice
2018 / Nature Communications
Web spiders synthesize silk fibers of unique strength and extensibility through the controlled self-assembly of protein building blocks, so-called spidroins.… Continue reading Two-step self-assembly of a spider silk molecular clamp
2018 / International Journal of Biological Macromolecules
Phospholipases A2 represent a family of enzymes with important application in medicine. However, direct tracking is difficult due to the absence… Continue reading In vitro tracking of phospholipase A2 from snake venom conjugated with magic-sized quantum dots
2018 / Marine Drugs
The hard clam Meretrix meretrix, which has been traditionally used as medicine and seafood, was used in this study to isolate… Continue reading Novel Bioactive Peptides from Meretrix meretrixProtect Caenorhabditis elegans against Free Radical-Induced Oxidative Stress through the Stress Response Factor DAF-16/FOXO
2018 / PLoS ONE
Sorting nexin 5 (SNX5), a member of sorting nexin family, plays an important role in membrane trafficking, including the retrograde… Continue reading The phosphorylation of sorting nexin 5 at serine 226 regulates retrograde transport and macropinocytosis
2019 / Phytochemistry
Root exudates from Lotus japonicus were found to contain at least three different hyphal branching-inducing compounds for the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, one of which… Continue reading Lotuslactone, a non-canonical strigolactone from Lotus japonicus
2018 / ACS Sustainable Chemistry & Engineering
RNA is a biopolymer of high relevance in the biopharmaceuticals field and in fundamental and applied research; however, the preservation… Continue reading Cholinium-based Good’s buffers ionic liquids as remarkable stabilizers and recyclable preservation media for recombinant small RNAs
2018 / Biochemical Journal
In plants and bacteria that use a Type II fatty acid synthase (FAS), isozymes of acyl-acyl carrier protein (ACP) thioesterase… Continue reading Identification of Active Site Residues Implies a Two-step Catalytic Mechanism for Acyl-ACP Thioesterase
2018 / Macromolecular Bioscience
Surgical site infections (SSI) represent a serious health problem that occur after invasive surgery, thus new antimicrobial biomaterials able to… Continue reading Silk‐Based Antimicrobial Polymers as a New Platform to Design Drug‐Free Materials to Impede Microbial Infections
2018 / Biophysical Journal
The human mitochondrial outer membrane protein VDAC2 (voltage-dependent anion channel) is a β-barrel metabolite flux channel that is indispensable for… Continue reading Hydrophobic mismatch modulates stability and plasticity of human mitochondrial VDAC2
