KnowledgeBase Articles Archive

Design, synthesis and characterization of novel chromone based-copper(II) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity

2018 / RSC Advances

A series of new chromone based-Cu(II) complexes 1–3 derived from bioactive pharmacophore, 3-formylchromone and N,N-donor ligands viz., 1,10-phenanthroline, 2,2′-bipyridine and 1R,2R-DACH were synthesized as… Continue reading Design, synthesis and characterization of novel chromone based-copper(II) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity

Different thermal processing effects on peanut allergenicity

2018 / Journal of the Science of Food and Agriculture

Peanut allergy is one of the most common food allergies worldwide. Studies have shown that the incidence of peanut allergies… Continue reading Different thermal processing effects on peanut allergenicity

Upconversion-chameleon-driven DNA computing: the DNA-unlocked inner-filter-effect (DU-IFE) for operating a multicolor upconversion luminescent DNA logic library and Its biosensing application

2018 / Materials Horizon

DNA computing has shown impressive developments and exhibited amazing power over the past few decades. However, most current DNA logic… Continue reading Upconversion-chameleon-driven DNA computing: the DNA-unlocked inner-filter-effect (DU-IFE) for operating a multicolor upconversion luminescent DNA logic library and Its biosensing application

Self-Assembly of Amphiphilic Schiff Base and Selectively Turn on Circularly Polarized Luminescence by Al3+

2018 / Langmuir

We designed glutamide-derived amphiphilic Schiff bases containing three different aldehyde moieties for the fabrication of circularly polarized luminescence (CPL) emitting… Continue reading Self-Assembly of Amphiphilic Schiff Base and Selectively Turn on Circularly Polarized Luminescence by Al3+

Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10

2018 / Phytochemistry Letters

Spirocurvulaide (1), a novel bicyclic polyketide with an unprecedented spiro[furan-2,2′-naphthalene] ring system, was produced by the fungus Curvularia sp. IFB-Z10 in a… Continue reading Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10

Pb2+ Binds to DREAM and Modulates Its Interactions with Binding Partners: a Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.

2018 / ACS Chemical Neuroscience

Pb2+ exposure leads to diverse neurological disorders; however, the mechanism of Pb2+-induced neurotoxicity is not clearly understood. Here we demonstrate that… Continue reading Pb2+ Binds to DREAM and Modulates Its Interactions with Binding Partners: a Link between Neuronal Calcium Sensors and Pb2+ Neurotoxicity.

Chemical synthesis of a two‐domain scorpion toxin LaIT2 and its single‐domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities

2018 / Journal of Peptide Science

Scorpion venom contains various bioactive peptides. Among them, peptides having two different structural domains constitute a toxin family known as… Continue reading Chemical synthesis of a two‐domain scorpion toxin LaIT2 and its single‐domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities

Identification and engineering of the key residues at the crevice-like binding site of lipases responsible for activity and substrate specificity

2018 / Biotechnology Letters

Rational engineering of the crevice-like binding site of lipases for improvement of lipases’ catalytic properties. The residues located at the… Continue reading Identification and engineering of the key residues at the crevice-like binding site of lipases responsible for activity and substrate specificity

Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers

2018 / The Journal of Organic Chemistry

Alternately N-alkylated aromatic amides such as 1 to 3 bearing various side chains were designed and synthesized as novel helical… Continue reading Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers

Limonoids Containing a C1–O–C29 Moiety: Isolation, Structural Modification, and Antiviral Activity

2018 / Marine Drugs

Five new limonoids named thaigranatins A–E (1–5), containing a C1–O–C29 moiety, were isolated from seeds of the Thai Xylocarpus granatum, collected at… Continue reading Limonoids Containing a C1–O–C29 Moiety: Isolation, Structural Modification, and Antiviral Activity

Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis

2018 / PLoS ONE

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and… Continue reading Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis

Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers

2018 / PLoS ONE

As an integral membrane protein, purification and characterization of phospho-N- acetylmuramyl- pentapeptide translocase MraY have proven difficult. Low yield and… Continue reading Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers

New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

2018 / Molecules

Five metabolites including two new ones, prochaetoviridin A (1) and chaetoindolin A (2), were isolated from the endophytic fungus Chaetomium globosum CDW7.… Continue reading New Metabolites from Endophytic Fungus Chaetomium globosum CDW7

Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes

2018 / ACS Omega

Herein, we describe a bright-red-emitting ovalbumin-protected gold nanoclusters (OVA–AuNCs) that were prepared and applied as a luminescent probe for a… Continue reading Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes

Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes

2018 / Molecules

Peptide amphiphile micelles (PAMs) are a nanoparticle platform that have gained popularity for their targeting versatility in a wide range… Continue reading Shape Effects of Peptide Amphiphile Micelles for Targeting Monocytes

Effects of selenate and red Se-nanoparticles on the photosynthetic apparatus of Nicotiana tabacum

2018 / Photosynthesis Research

Selenium (Se) is a natural trace element, which shifts its action in a relatively narrow concentration range from nutritional role… Continue reading Effects of selenate and red Se-nanoparticles on the photosynthetic apparatus of Nicotiana tabacum

Inhibition of amyloid fibril formation of β-lactoglobulin by the natural and synthetic curcuminoids

2018 / New Journal of Chemistry

The aggregation of proteins have been associated with several aspects of daily life, including food processing, blood coagulation and many… Continue reading Inhibition of amyloid fibril formation of β-lactoglobulin by the natural and synthetic curcuminoids

Novel Amphiphillic G-quadruplex Binding Synthetic Derivative of TMPyP4 and its Effect on Cancer Cell Proliferation and Apoptosis Induction

2018 / Biochemistry

Porphyrins are well known anticancer agents due to their higher binding affinity to G-quadruplex DNA and excellent photophysical properties. Several… Continue reading Novel Amphiphillic G-quadruplex Binding Synthetic Derivative of TMPyP4 and its Effect on Cancer Cell Proliferation and Apoptosis Induction

Characterizing the noncovalent binding behavior of tartrazine to lysozyme: A combined spectroscopic and computational analysis

2018 / Journal of Biochemical and Molecular Toxicology

Tartrazine is a stable water‐soluble azo dye widely used as a food additive, which could pose potential threats to humans… Continue reading Characterizing the noncovalent binding behavior of tartrazine to lysozyme: A combined spectroscopic and computational analysis

A study on the interaction between cadmium and α‐chymotrypsin and the underlying mechanisms