Found 9617 Results / Page 202 of 481
2018 / Molecular Pharmaceutics
Peptide aggregation such as the formation of fibrils could pose a significant challenge for the stability of parenteral peptide drugs.… Continue reading Fibril Nucleation Kinetics of a Pharmaceutical Peptide: The Role of Conformation Stability, Formulation Factors, and Temperature Effect
2018 / RSC Advances
Separating a target product from a relatively complex bioreaction system is often difficult. In this work, a “smart” bioreaction system… Continue reading Thermally controlled biotransformation of glycyrrhizic acid via an asymmetric temperature-responsive polyurethane membrane
2018 / Scientific Reports
Pseudoaldosteronism is a common adverse effect associated with traditional Japanese Kampo medicines. The pathogenesis is mainly caused by 3-monoglucuronyl glycyrrhetinic… Continue reading Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism
2019 / Enzyme and Microbial Technology
The exploitation of SUMO (small ubiquitin-related modifier) fusion technology at a large scale for the production of therapeutic proteins with an authentic N-terminus is… Continue reading Bioprocess optimization for the overproduction of catalytic domain of ubiquitin-like protease 1 (Ulp1) from S. cerevisiaein E. coli fed-batch culture
2019 / Phytochemistry
Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus… Continue reading Alkaloids and styryllactones from Goniothalamus cheliensis
2018 / ACS Infectious Diseases
Computer-aided screening of antimicrobial peptides (AMPs) is a promising approach for discovering novel therapies against multidrug-resistant bacterial infections. Here, we… Continue reading A computationally designed peptide derived from Escherichia colias a potential drug template for antibacterial and antibiofilm therapies
2018 / Analyst
We have previously reported a novel method for measuring the spectral properties and orientation of fluorescent probes in solution, which… Continue reading Fluorescence detected linear dichroism of small molecules oriented on polyethylene film
2018 / Journal of Peptide Science
Among the insulin‐family peptides, two additional cysteine residues other than six conserved cysteines are sometimes found in invertebrate insulin‐like peptides… Continue reading Chemical synthesis of the crustacean insulin‐like peptide with four disulfide bonds
2018 / Bioconjugate Chemistry
Synthetic antibacterial peptides are advanced weapons that scientists design and produce facing current treats due to harmful and mortal pathogens,… Continue reading Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria in Submicromolar Concentration
2018 / Langmuir
Microbial extracellular electron transport occurs via the physical and electrical association of outer-membrane c-type cytochromes (OM c-Cyts) with extracellular solid… Continue reading Geometrical Changes in the Hemes of Bacterial Surface c-type Cytochromes Reveal Flexibility in their Binding Affinity with Minerals
2018 / Bioconjugate Chemistry
Manipulating the chiroptical at the nanoscale is of great importance in stereoselective reactions, enantioseparation, self assembly and biological phenoma. In… Continue reading Chirality Inversion on the Carbon Dot Surface via Covalent Surface Conjugation of Cyclic α-Amino Acid Capping Agents
2018 / PLoS ONE
The IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) gene has a role in skeletal muscle function and is… Continue reading Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma
2018 / Dalton Transactions
Eight novel Tl(I) β-oxodithioester complexes, [TlL]n (1–8) with ligands, L = methyl-3-hydroxy-3-(2-furyl)-2-propenedithioate (L1), methyl-3-hydroxy-3-(2-thienyl)-2-propenedithioate (L2), methyl-3-hydroxy-3-(3-pyridyl)-2-propenedithioate (L3), methyl-3-hydroxy-3-(4-pyridyl)-2-propenedithioate (L4), methyl-3-hydroxy-3-(9-anthracenyl)-2-propenedithioate… Continue reading Cooperative Metal–Ligand Influence on the Formation of Coordination Polymers, Conducting and Photophysical Properties of Tl(I) β-oxodithioester Complexes
2018 / Advanced Healthcare Materials
Flash nanoprecipitation (FNP) by fast mixing of drug‐containing organic solvent and water in a microchamber is a powerful and scalable… Continue reading Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation
2019 / International Journal of Biological Macromolecules
Thrombolytic agents are routinely used to dissolve blood clot by activating fibrinolytic system. Among different thrombolytic agents available, staphylokinase (SAK) is gaining… Continue reading Lipid modification of staphylokinase and its implications on stability and activity
2018 / Biochemistry
Cytochrome c peroxidases (bCcPs) are diheme enzymes required for the reduction of H2O2 to water in bacteria. There are two… Continue reading Resonance Raman, EPR and MCD Spectroscopic Investigation of Diheme Cytochrome c Peroxidases from Nitrosomonas europaea and Shewanella oneidensis
2018 / ACS Omega
Atrazine is an herbicide that is widely used in crop production at about 70 million pounds per year in the… Continue reading In Vitro Selection and Characterization of a Single-Stranded DNA Aptamer Against the Herbicide Atrazine
2018 / Organic & Biomolecular Chemistry
Baefrutones A–F (1–6), six new meroterpenoids with rare triketone-phloroglucinol-monoterpene/sesquiterpene frameworks, together with their biosynthetically related intermediate (±)-baeckenon B (7), were… Continue reading Atropisomeric meroterpenoids with rare triketone-phloroglucinol-terpene hybrids from Baeckea frutescens
2018 / Advanced Healthcare Materials
Protein therapeutics are prone to lose their structure and bioactivity under various environmental stressors. This study reports a facile approach… Continue reading Metal‐Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics
2018 / ChemBioChem
Aggregation of intrinsically disordered proteins into fibrils is implicated in many neurodegenerative diseases. Amyloid aggregation is a generic property of… Continue reading Amyloid aggregation of Bacillus circulans xylanase under a native condition and its modulation by beta‐amyloid‐derived peptide fragments
