Found 9617 Results / Page 217 of 481
2018 / Scientific Reports
The occurrence of triplexes in vivo has been well documented and is determined by the presence of long homopurine-homopyrimidine tracts. The formation… Continue reading Modified RNA triplexes: Thermodynamics, structure and biological potential
2018 / Protein Science
Disulfide‐rich peptides represent an important protein family with broad pharmacological potential. Recent advances in computational methods have made it possible… Continue reading Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide‐rich de novo designed peptides
2018 / Journal of Biological Chemistry
Protein-minimization is an attractive approach for designing vaccines against rapidly evolving pathogens such as HIV-1 since it can help in… Continue reading Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4 binding site neutralizing antibodies
2018 / ACS Applied Materials & Interfaces
Discovering new strategies for combating drug-resistant tumors becomes a worldwide challenge. Thereinto, stubborn drug-resistant tumor membrane is a leading obstacle… Continue reading Engineering Anticancer Amphipathic Peptide-Dendronized Compounds for Highly-Efficient Plasma/Organelle Membrane Perturbation and Multidrug Resistance Reversal
2018 / Microchimica Acta
A one-step, one-tube colorimetric assay is described for the detection of bacterial double-stranded DNA (dsDNA). It utilizes a G-quadruplex DNAzyme… Continue reading Determination of bacterial DNA based on catalytic oxidation of cysteine by G-quadruplex DNAzyme generated from asymmetric PCR: Application to the colorimetric detection of Staphylococcus aureus
2018 / Physical Chemistry Chemical Physics
In this work, the interaction of six natural benzo[c]phenanthridine alkaloids (macarpine, sanguilutine, sanguirubine, chelerythrine, sanguinarine and chelirubine) with parallel and… Continue reading Naturally occurring quaternary benzo[c]phenanthridine alkaloids selectively stabilize G-quadruplexes
2018 / Nature Photonics
Hybrid organic–inorganic perovskites exhibit strong spin–orbit coupling1, spin-dependent optical selection rules2,3 and large Rashba splitting4,5,6,7,8. These characteristics make them promising candidates… Continue reading Spin control in reduced-dimensional chiral perovskites
2018 / Scientific Reports
A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and… Continue reading Turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA based upon Y-shaped DNA structure
2018 / Biomacromolecules
Antimicrobial peptides (AMPs) such as LL37 are promising alternatives to antibiotics to treat wound infections due to their broad activity,… Continue reading Concentration-Dependent, Membrane-Selective Activity of Human LL37 Peptides Modified with Collagen Binding Domain Sequences
2018 / Journal of Materials Chemistry B
Multifunctional carbon dots (CDs) with lifetime thermal sensing, nucleolus imaging, and antialgal activity properties were synthesized directly from ascorbic acid… Continue reading Multifunctional carbon dot for lifetime thermal sensing, nucleolus imaging and antialgal activity
2018 / Organic & Biomolecular Chemistry
The development of γ-thionorleucine (ThioNle) as a handle for native chemical ligation–desulfurization is reported here. ThioNle is a new addition… Continue reading Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation
2018 / Journal of Agricultural and Food Chemistry
Five new resorcylic acid lactones (RALs) hispidulactones A–E (1, 4, 5, 8, and 9), a new natural product (2), and four known ones (3, 6, 7,… Continue reading Bioactive Resorcylic Acid Lactones with Different Ring Systems from Desert Plant Endophytic Fungus Chaetosphaeronema hispidulur
2018 / The Journal of Physical Chemistry A
Because of the unique interaction of radial aromatic blades, propeller-shaped hexaarylbenzenes (HABs) attract much research interest and find various practical… Continue reading Solvent and Temperature Effects on Dynamics and Chiroptical Properties of Propeller Chirality and Toroidal Interaction of Hexaarylbenzenes
2018 / Scientific Reports
Adenosine Kinase (ADK) regulates the cellular levels of adenosine (ADO) by fine-tuning its metabolic clearance. The transfer of γ-phosphate from… Continue reading Adenosine Kinase couples sensing of cellular potassium depletion to purine metabolism
2018 / European Biophysics Journal
Chemical modification of therapeutic peptides is an important approach to improving their physicochemical and pharmacokinetic properties. The triphenylphosphonium (TPP) cation… Continue reading Effect of triphenylphosphonium moiety on spatial structure and biointeractions of stereochemical variants of YRFK motif
2018 / The FEBS Journal
Many patients under therapy with recombinant human erythropoietin (rhuEPO) show resistance to the treatment, an effect likely associated with the… Continue reading Modification of erythropoietin structure by N‐homocysteinylation affects its antiapoptotic and proliferative functions
2018 / Polymers
An optically active, amphiphilic meta-phenylene ethynylene (m-PE) bearing a chiral amide pendant was designed and synthesized. Living polymerization of m-PE using alkyne-Pd(II)… Continue reading A Facile Synthetic Route to Amphiphilic Poly(Meta-Phenylene Ethynylene) and Poly(Meta-Phenylene Ethynylene)-Block-Polyisocyanide Using a Single Catalyst
2018 / Acta Pharmaceutica Sinica B
Five new sulfur-enriched alkaloids isatithioetherins A−E (1−5), and two pairs of scalemic enantiomers (+)- and (−)-isatithiopyrin B (6a and 6b) and isoepigoitrin… Continue reading Sulfur-enriched alkaloids from the root of Isatis indigotica
2018 / Organic & Biomolecular Chemistry
Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol.… Continue reading Attenuation of guanine oxidation via DNA-mediated electron transfer in crowded environment using small cosolutes
2018 / Scientific Reports
Sweet proteins are an unexploited resource in the search for non-carbohydrate sweeteners mainly due to their low stability towards heating.… Continue reading Protein stabilization with retained function of monellin using a split GFP system
