KnowledgeBase Articles

By screening 25 different psychrophilic strains isolated from the Arctic habitat, we isolated a strain capable of producing lipase. We… Continue reading Purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from Psychrobacter sp. ZY124

The functionalization of alumina nanoparticles of specific morphology with antimicrobial peptides (AMP) can be a promising strategy for modeling medical… Continue reading Nanobiostructure of fibrous-like alumina functionalized with an analog of the BP100 peptide: Synthesis, characterization and biological applications

Pro-domain of a cysteine cathepsin contains a highly conserved Ex2Rx2Fx2Nx3Ix3N (ERFNIN) motif. The zymogen structure of cathepsins revealed that the… Continue reading Highly Conserved Arg Residue of ERFNIN Motif of Pro-Domain is Important for pH-Induced Zymogen Activation Process in Cysteine Cathepsins K and L

A fluorescent method is described for simultaneous recognition of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). It is based on… Continue reading A gold nanoparticle based fluorescent probe for simultaneous recognition of single-stranded DNA and double-stranded DNA

A new chiral mononuclear Dy(III) complex, [Dy((-)-pbipy)(pdtc)3] (1) (pbipy = 4,5-pinene-2,2′-bipyridine, pdtc = pyrrolidine-dithiocarbamate) has been synthesized and structurally characterized. Magnetic studies show that… Continue reading Chiral mononuclear Dy(III) complex based on pyrrolidine-dithiocarboxylate S-donors with field-induced single-ion magnet behavior

Protease inhibitors from plants play major role in defensive mechanism against various pathogenic organisms. AMTIN from the tubers of Alocasia macrorrhiza has… Continue reading Structural insights into a multifunctional inhibitor, ‘AMTIN’ from tubers of Alocasia macrorrhizos and its possible role in dengue protease (NS2B-NS3) inhibition

Some tetrahydroisoindoline-1,3-dione derivatives (TDDs) possess potent herbicidal activity. To assess possible impacts of TDDs on humans, the interactions between TDDs… Continue reading Interactions between tetrahydroisoindoline-1,3-dione derivatives and human serum albumin via multiple spectroscopy techniques

Efficient methodology for simultaneous extraction of multiple bioactive compounds from microalgae still remains a major challenge. The present study provides… Continue reading An efficient method for the sequential production of lipid and carotenoids from the Chlorella Growth Factor-extracted biomass of Chlorella vulgaris

Guanine-rich DNA strands have the potential to activate Cu2+ ions in peroxidase-like reactions based on the coordination of Cu2+ with nucleobases. Comparative… Continue reading Hunting for the “Sweet Spot”: Effects of Contiguous Guanines and Strand Lengths on the Catalytic Performance of DNA-Based Peroxidase Mimetics

The purpose of this study was to fabricate redox-responsive human serum albumin(HSA) nanoparticles (NPs) through self-assembly of HSA molecules for incorporation… Continue reading Redox responsive curcumin-loaded human serum albumin nanoparticles: Preparation, characterization and in vitroevaluation

The binding effect of gemini surfactant, hexanediyl-α,ω-bis-(N-(2-hydroxyethyl)–N-methylhexadecylammonium bromide) (16-6-16 MEA) and its monomeric counterpart N-(2-hyroxyethyl)-N,N-dimethylhexadecylammonium bromide (16-MEA) on the structure and esterase… Continue reading Effect of cationic gemini surfactant and its monomeric counterpart on the conformational stability and esterase activity of human serum albumin

Light-driven atropisomeric polymers containing azo and binaphthyl units with a conjugated structure were designed and synthesized. The polymers exhibit a… Continue reading Light-driven molecular switching of atropisomeric polymers containing azo-binaphthyl groups in their side chains

Triblock copolymers, such as Pluronic F127 (F127), are pharmaceutically important amphiphilic compounds that self-assemble in aqueous solution either as discrete… Continue reading Molecular interactions between Pluronic F127 and the peptide tritrpticin in aqueous solution

Molybdenum disulfide (MoS2), a type of transition metal dichalcogenide material, has emerged as an important class among 2D systems. When… Continue reading Chiral MoS2 Quantum Dots: Dual‐Mode Detection Approaches for Avian Influenza Viruses

The thiol-disulfide redox metabolism in platyhelminth parasites depends entirely on a single selenocysteine (Sec) containing flavoenzyme, thioredoxin glutathione reductase (TGR)… Continue reading Biochemical and thermodynamic comparison of the selenocysteine containing and non-containing thioredoxin glutathione reductase of Fasciola gigantica

Polyoxometalates (POMs) are multi metallic and polyanionic oxides whose functionalization with organic moieties can generate new properties. Among possible strategies… Continue reading Synthesis and biological activity of an Anderson polyoxometalate bis‐functionalized with a Bombesin‐analog peptide

Methylglycine, also known sarcosine, is dramatically used in drug molecules and its metal complexes can interact to DNA and also… Continue reading Improving of Anticancer Activity and Solubility of Cisplatin by Methylglycine and Methyl Amine Ligands Against Human Breast Adenocarcinoma Cell Line

Insulin, as one of the most important hormones regulating energy metabolism, plays an essential role in maintaining glucose and lipid… Continue reading A novel peptide Phylloseptin‐PBu from Phyllomedusa burmeisteripossesses insulinotropic activity via potassium channel and GLP‐1 receptor signalling

Methylglyoxal (MGO), a reactive dicarbonyl metabolite is a potent arginine directed glycating agent which has implications for diabetes-related complications. Dicarbonyl… Continue reading Biophysical and biochemical studies on glycoxidatively modified human low density lipoprotein

The conformation of lens protein α crystallin was investigated using different spectroscopic techniques under normal and UV-C-irradiated condition. The structural… Continue reading Aberration in the structural paradigm of lens protein α crystallin by UV-C irradiation