KnowledgeBase Articles Archive

Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

2018 / Analytica Chimica Acta

Target selectivity is one of the main challenges in the search for small molecules able to act as effective and… Continue reading Controlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligands

Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site

2018 / International Journal of Biological Macromolecules

Chikungunya virus (CHIKV), a mosquito-borne pathogenic alphavirus is a growing public health threat. No vaccines or antiviral drug is currently… Continue reading Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site

Isolation of novel biflavonoids from Cardiocrinum giganteumseeds and characterization of their antitussive activities

2018 / Journal of Ethnopharmacology

Seeds of Cardiocrinum giganteum var. yunnanense (Leichtlin ex Elwes) Stearn (Liliaceae), also known as Doulingzi, have been used as a… Continue reading Isolation of novel biflavonoids from Cardiocrinum giganteumseeds and characterization of their antitussive activities

Molecular dynamics-based model of VEGF-A and its heparin interactions

2018 / Journal of Molecular Graphics and Modelling

We present a computational model of the Vascular Endothelial Growth Factor (VEGF), an important regulator of blood vessels formation, which… Continue reading Molecular dynamics-based model of VEGF-A and its heparin interactions

Highly Efficient Deracemization of Racemic 2-Hydroxy Acids in a Three-Enzyme Co-Expression System Using a Novel Ketoacid Reductase

2018 / Applied Biochemistry and Biotechnology

Enantiopure 2-hydroxy acids (2-HAs) are important intermediates for the synthesis of pharmaceuticals and fine chemicals. Deracemization of racemic 2-HAs into… Continue reading Highly Efficient Deracemization of Racemic 2-Hydroxy Acids in a Three-Enzyme Co-Expression System Using a Novel Ketoacid Reductase

Novel Naphthalimide Derivatives as Selective G-Quadruplex DNA Binders

2018 / Applied Biochemistry and Biotechnology

A new derivate of 4-bromo-1,8-naphthalic anhydride and its quaternized analogue have been prepared and characterized. The interactions of both derivatives… Continue reading Novel Naphthalimide Derivatives as Selective G-Quadruplex DNA Binders

Improved charge carrier dynamics in polymer/perovskite nanocrystal based hybrid ternary solar cells

2018 / Physical Chemistry Chemical Physics

Here, brand new ternary hybrid solar cells comprising perovskite nanocrystals (NCs) with a complementary absorption profile of the organic host… Continue reading Improved charge carrier dynamics in polymer/perovskite nanocrystal based hybrid ternary solar cells

Highly Luminescent Organic Nanorods from Air Oxidation of para‐Substituted Anilines for Freestanding Deep‐Red Color Filters

2018 / Advanced Optical Materials

Oxidation of aniline provides useful organic nanostructures with a wide variety of particle morphologies and properties. Accordingly, in the present… Continue reading Highly Luminescent Organic Nanorods from Air Oxidation of para‐Substituted Anilines for Freestanding Deep‐Red Color Filters

Luminescent and Transparent Nanocellulose Films Containing Europium Carboxylate Groups as Flexible Dielectric Materials

2018 / ACS Applied Nanomaterials

Transparent, flexible, and luminescent 2,2,6,6-tetramethyl-piperidine-1-oxyl radical-oxidized cellulose nanofibril films with europium carboxylate groups (TOCN-Eu) are proposed as potential flexible dielectric… Continue reading Luminescent and Transparent Nanocellulose Films Containing Europium Carboxylate Groups as Flexible Dielectric Materials

Hybrids Based on Graphene Oxide and Porphyrin as Tools for Detection and Stabilization of DNA G-Quadruplexes

2018 / ACS Omega

Telomerase inhibition has been an important strategy in cancer therapies, but for which effective drugs are still required. Here, noncovalent… Continue reading Hybrids Based on Graphene Oxide and Porphyrin as Tools for Detection and Stabilization of DNA G-Quadruplexes

Formation of emissive nanoparticles from tetraphenylethylene-containing boronate macrocycles: preparation, characterization and functionalization

2018 / Journal of Materials Chemistry C

[2+2] Macrocycles composed of two tetraphenylethylenes (TPEs) and two linkers, namely 1a (R = H) and 1b (R = NO2), were prepared in a… Continue reading Formation of emissive nanoparticles from tetraphenylethylene-containing boronate macrocycles: preparation, characterization and functionalization

Fluorescence emission and interaction nature of protein coated gold and copper nanoclusters at different ionic environments as ion sensor

2018 / Journal of Physics D: Applied Physics

Lysozyme protein induced luminescent gold and copper nanoclusters (AuNCs and CuNCs) are prepared and their sensing ability is studied in… Continue reading Fluorescence emission and interaction nature of protein coated gold and copper nanoclusters at different ionic environments as ion sensor

Structural characterization of a fluorescein hydrazone molecular switch with application towards logic gates

2018 / New Journal of Chemistry

A fluorescein acylhydrazone (2) as well as its metal complexes with Zn2+, Ni2+ and Cu2+ ions were synthesized and characterized… Continue reading Structural characterization of a fluorescein hydrazone molecular switch with application towards logic gates

Chiral self-sorted multifunctional supramolecular biocoordination polymers and their applications in sensors

2018 / Nature Communications

Chiral supramolecules have great potential for use in chiral recognition, sensing, and catalysis. Particularly, chiral supramolecular biocoordination polymers (SBCPs) provide… Continue reading Chiral self-sorted multifunctional supramolecular biocoordination polymers and their applications in sensors

Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

2018 / RSC Advances

Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal… Continue reading Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane

RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain

2018 / Nucleic Acids Research

hnRNPA1 is a member of heteronuclear ribonucleoproteins that has been shown to promote telomere elongation apart from its roles in… Continue reading RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain

A Minimalist Approach for Distinguishing Individual Lanthanide Ions Using Multivariate Pattern Analysis

2018 / ACS Sensors

To discriminate among the 14 trivalent lanthanide ions, curcumin, a naturally occurring, nontoxic, off-the-shelf, commercially available compound containing a single… Continue reading A Minimalist Approach for Distinguishing Individual Lanthanide Ions Using Multivariate Pattern Analysis

A single residue switch reveals principles of antibody domain integrity

2018 / Journal of Biological Chemistry

Despite their importance for antibody architecture and design, the principles governing antibody domain stability are still not understood in sufficient… Continue reading A single residue switch reveals principles of antibody domain integrity

Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme

2018 / International Journal of Biological Macromolecules

The study investigates the role of the electrostatic interactions in the fibrillation of the hen egg white lysozyme (HEWL). In order to achieve this… Continue reading Influence of the ionic strength on the amyloid fibrillogenesis of hen egg white lysozyme

Spectrochemical and theoretical approaches for acylhydrazone-based fluoride sensors

2018 / Research on Chemical Intermediates

Acylhydrazone derivatives N′-[1-(2-fluorophenyl)ethylidene]pyridine-3-carbohydrazide (R1) and N′-[2-fluorobenzylidene]benzohydrazide (R2) were synthesized from their corresponding hydrazides and characterized by spectroscopic methods. The response of these… Continue reading Spectrochemical and theoretical approaches for acylhydrazone-based fluoride sensors

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