The effects of visible light on biological systems have been widely studied. In particular, the alterations of blue light on… Continue reading Effects of green and red light in βL-crystallin and ovalbumin
Leah Pandiscia, PhD
August 13, 2018
Carboxydothermus hydrogenoformans is a model microorganism for the study of [NiFe]–CODH, a key enzyme of carbon cycle in anaerobic microorganisms. The enzyme… Continue reading Biophysical and structural characterization of the putative nickel chaperone CooT from Carboxydothermus hydrogenoformans
Leah Pandiscia, PhD
August 13, 2018
Thermoplasma acidophilum is a thermophilic archaeon that uses both non-phosphorylative Entner-Doudoroff (ED) pathway and Embden-Meyerhof-Parnas (EMP) pathway for glucose degradation. While… Continue reading Structure and Stability of the Dimeric Triosephosphate Isomerase from the Thermophilic Archaeon Thermoplasma acidophilum
Leah Pandiscia, PhD
August 13, 2018
Binding interaction of Bovine Serum Albumin (BSA) with newly prepared rhodamine 6G-capped gold nanoparticles (Rh6G-Au NPs) under physiological conditions (pH 7.2)… Continue reading Multispectroscopic and bioimaging approach for the interaction of rhodamine 6G capped gold nanoparticles with bovine serum albumin
Leah Pandiscia, PhD
August 13, 2018
Zingiber officinale Roscoe (Ginger) is a widely used traditional medicinal plant (for different ailments such as arthritis, constipation, and hypertension). This… Continue reading Isolation and initial structural characterization of a 27 kDa protein from Zingiber officinale
Leah Pandiscia, PhD
August 13, 2018
Integrin-linked kinase (ILK) is a ubiquitously expressed Ser/Thr kinase which plays significant role in the cell-matrix interactions and growth factor… Continue reading Unravelling the unfolding mechanism of human integrin linked kinase by GdmCl-induced denaturation
Leah Pandiscia, PhD
August 13, 2018
Pre-mRNA processing protein 40 (Prp40) is a nuclear protein that has a role in pre-mRNA splicing. Prp40 possesses two leucine-rich nuclear export signals, but little is… Continue reading Prp40 Homolog A Is a Novel Centrin Target
Leah Pandiscia, PhD
August 13, 2018
Integrin-linked kinase (ILK), a ubiquitously expressed intracellular Ser/Thr protein kinase, plays a major role in the oncogenesis and tumour progression. The conformational stability and unfolding… Continue reading Mechanistic insights into the urea-induced denaturation of kinase domain of human integrin linked kinase
Leah Pandiscia, PhD
August 13, 2018
In this work the influences of κ-carrageenan (CRG), konjac glucomannan (KGM) and inulin on lysozyme (Ly)’s structure, activity, and their complex… Continue reading Effect of physical interactions on structure of lysozyme in presence of three kinds of polysaccharides
Leah Pandiscia, PhD
August 13, 2018
Nanoparticles (NPs) exhibiting responsiveness towards pH variations in organs, tissue microenvironments and cellular compartments can significantly add on to the… Continue reading Arginine-α, β-dehydrophenylalanine Dipeptide Nanoparticles for pH-Responsive Drug Delivery
Leah Pandiscia, PhD
August 13, 2018
In this present work, a detailed investigation of the effect of an anticancer drug, 5-Fluorouracil (5-FU), on conformation, stability and activity of lysozyme (Lyz) was… Continue reading Exploring the effect of 5-Fluorouracil on conformation, stability and activity of lysozyme by combined approach of spectroscopic and theoretical studies
Leah Pandiscia, PhD
August 13, 2018
Eight new cyclizidine-type alkaloids (1–8) and one known alkaloid (9) were identified from the chemical investigations of a marine-derived actinomycete, Streptomyces sp.… Continue reading Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Evidence is mounting that the major histocompatibility complex (MHC) molecule HLA-F (human leukocyte antigen F) regulates the immune system in pregnancy, infection, and autoimmunity by… Continue reading Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors
Leah Pandiscia, PhD
August 13, 2018
Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A–D (1–4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by… Continue reading New ellagitannins from Tiencha and their inhibitory activity against dental plaque
Leah Pandiscia, PhD
August 13, 2018
Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V–VIII were… Continue reading New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1
Leah Pandiscia, PhD
August 13, 2018
Certain amphiphilic block copolymers are known to prevent aggregation of unfolded proteins. To better understand the mechanism of this effect,… Continue reading Amphiphilic copolymers reduce aggregation of unfolded lysozyme more effectively than polyethylene glycol
Leah Pandiscia, PhD
August 13, 2018
The Nogo-B receptor (NgBR) is involved in oncogenic Ras signaling through directly binding to farnesylated Ras. It recruits farnesylated Ras… Continue reading SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains
Leah Pandiscia, PhD
August 13, 2018
Surging reports of peptide-based nanosystems and their growing potency in terms of biological utility demand for the search of newer… Continue reading Nanoparticles generated from a tryptophan derivative: physical characterization and anti-cancer drug delivery
Leah Pandiscia, PhD
August 13, 2018
Modular polyketide synthases (PKSs) produce numerous structurally complex natural products that have diverse applications in medicine and agriculture. PKSs typically… Continue reading Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases
Leah Pandiscia, PhD
August 13, 2018