Leah Pandiscia, PhD
August 13, 2018
Nanobodies represent the variable binding domain of camelid heavy-chain antibodies and are employed in a rapidly growing range of applications… Continue reading The structural basis of nanobody unfolding reversibility and thermoresistance
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
The peptide VLL-28, identified in the sequence of an archaeal protein, the transcription factor Stf76 from Sulfolobus islandicus, was previously… Continue reading Insights into the anticancer properties of the first antimicrobial peptide from Archaea
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
We stapled an amphipathic peptide mainly consisting of leucine (L) and lysine (K) by an azobenzene (Ab) linker for photo-control… Continue reading Photo-Switching of Cell Penetration of Amphipathic Peptides by Control of Alpha-Helical Conformation
Leah Pandiscia, PhD
August 13, 2018
The three-fingered toxin family and more precisely short-chain α-neurotoxins (also known as Type I α-neurotoxins) are crucial in defining the… Continue reading Short-chain consensus alpha-neurotoxin: a synthetic 60-mer peptide with generic traits and enhanced immunogenic properties
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Therapeutic biologics (i.e., proteins) have been widely recognized for the treatment, prevention, and cure of a variety of human diseases… Continue reading Recombinant Spider Silk Hydrogels for Sustained Release of Biologicals
Leah Pandiscia, PhD
August 13, 2018
Proteins undergo both cold and heat denaturation, but often cold denaturation cannot be detected because it occurs at temperatures below… Continue reading The cold denaturation of IscU highlights structure–function dualism in marginally stable proteins
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
The synthesis and the impact of a disulfide bridge between 2′-O-positions of two adjacent nucleotides in an RNA duplex and… Continue reading A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins
Leah Pandiscia, PhD
August 13, 2018
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium… Continue reading Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect
Leah Pandiscia, PhD
August 13, 2018
Phloroglucinol and its derivatives possess wide array of biopotentials such as antimicrobial, antioxidant, anti-inflammatory, anticancer and anti-metastatic properties. In the present investigation, for the first time,… Continue reading Molecular interaction between human serum albumin (HSA) and phloroglucinol derivative that shows selective anti-proliferative potential
Leah Pandiscia, PhD
August 13, 2018
The binding mode of thionine (3,7-diamino-5-phenothiazinium) with alternating and non-alternating DNA polynucleotides at low binding ratios was conclusively determined using linear and circular dichroism spectroscopies. The… Continue reading Linear and circular dichroism characterization of thionine binding mode with DNA polynucleotides
Leah Pandiscia, PhD
August 13, 2018
Ni(II) stimulates innate immunity via the direct binding to human Toll Like Receptor 4(hTLR4), the bacterial lypopolysaccharide receptor. The binding is specific for humans… Continue reading Ni(II) interaction with a peptide model of the human TLR4 ectodomain
Leah Pandiscia, PhD
August 13, 2018
Activation-induced cytidine deaminase (AID) initiates both class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. Mechanisms of AID targeting… Continue reading AID Recognizes Structured DNA for Class Switch Recombination
Leah Pandiscia, PhD
August 13, 2018
Callistrilones F–K (1–6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with… Continue reading Antiviral Triketone‐Phloroglucinol‐Monoterpene Adducts from Callistemon rigidus
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018