α-synuclein plays a key role in the pathogenesis of Parkinson’s disease (PD); its deposits are found as amyloid fibrils in… Continue reading Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates
Leah Pandiscia, PhD
August 13, 2018
In order to determine the eutomers of potent GluN2B selective NMDA receptor antagonists with 3‐benzazepine scaffold, benzyl ethers (S)‐2 and… Continue reading Synthesis and pharmacological evaluation of enantiomerically pure GluN2B selective NMDA receptor antagonists
Leah Pandiscia, PhD
August 13, 2018
Oligomeric assembly is a common feature of membrane proteins and often relevant to their physiological functions. Determining the stoichiometry and… Continue reading Oligomeric states of microbial rhodopsins determined by high-speed atomic force microscopy and circular dichroic spectroscopy
Leah Pandiscia, PhD
August 13, 2018
As a left-handed helical structure, Z-DNA is biologically active and it may be correlated with transcription and genome stability. Until… Continue reading The Cucurbit[7]Uril-Based Supramolecular Chemistry for Reversible B/Z-DNA Transition
Leah Pandiscia, PhD
August 13, 2018
A G‐quadruplex forming sequence from the MYC promoter region was modified with syn‐favoring 8‐bromo‐2’‐deoxyguanosine residues. Depending on the number and… Continue reading Loop Length Affects Syn‐Anti Conformational Rearrangements in Parallel G‐Quadruplexes
Leah Pandiscia, PhD
August 13, 2018
The allosteric interplay between distant functional sites present in a single protein provides for one of the most important regulatory… Continue reading Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
Leah Pandiscia, PhD
August 13, 2018
Polymyxin is the last line of defense against severe infections caused by carbapenem-resistant gram-negative pathogens. The emergence of transferable MCR-1/2… Continue reading Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis
Leah Pandiscia, PhD
August 13, 2018
The photo-induced reconfigurable assembly of nanostructures via the simultaneous noncovalent and covalent polymerization of a functional ferrocene-tyrosine (Fc-Y) molecule is… Continue reading Photo-Induced Polymerization and Reconfigurable Assembly of Multifunctional Ferrocene-Tyrosine
Leah Pandiscia, PhD
August 13, 2018
Suppressor of cytokine signaling (SOCS) family of proteins plays critical role in the regulation of immune responses controlling JAK/STAT mediated… Continue reading Mimetics of Suppressor of cytokine signalling 3: novel potential therapeutics in triple breast cancer
Leah Pandiscia, PhD
August 13, 2018
Antimicrobial peptides (AMPs) are a diverse group of molecules which play an important role in the innate immune response. Bovine… Continue reading Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis
Leah Pandiscia, PhD
August 13, 2018
We have shown that fullerene (C60) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril… Continue reading Preparation and photo-induced activities of water-soluble amyloid β-C60 complexes
Leah Pandiscia, PhD
August 13, 2018
The construction of sensitive and selective biosensors capable of detecting specific targets in complex biological samples remains a challenge highly… Continue reading Low Fouling Protein Detection in Complex Biological Media Supported by a Designed Multifunctional Peptide
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
NsaS is one of four intramembrane histidine kinases (HKs) in Staphylococcus aureus that mediate the pathogen’s response to membrane active… Continue reading Structure and function of the transmembrane domain of NsaS, an antibiotic sensing histidine kinase in S. aureus
Leah Pandiscia, PhD
August 13, 2018
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney disease. Here we show mutations in… Continue reading Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
Leah Pandiscia, PhD
August 13, 2018
The reactions of hexaazamacrocycle 1 with 2,6-bis(bromomethyl)pyridine or 2,6-bis[(tosyloxy)methyl)]pyridine in the presence of appropriate carbonates result in the formation of… Continue reading Chiral Cryptates Derived from a Hexa-azamacrocycle
Leah Pandiscia, PhD
August 13, 2018
In this paper, we report our investigations on analogues of the anti-human immunodeficiency virus type 1 (HIV-1) integrase (IN) aptamer T30175… Continue reading Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Dentin phosphoprotein (DPP) is a major component of the dentin matrix playing crucial role in hydroxyapatite deposition during bone mineralization,… Continue reading Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization
Leah Pandiscia, PhD
August 13, 2018
Using enantiopure ligands (–)/(+)-4,5-pinene-2,2ʹ-bipyridine (LR/LS) to react with Dy(btfa)3•2H2O, respectively, a pair of Dy(III) enantiomers with the formulae Dy(btfa)3LR (R-1… Continue reading A pair of mononuclear Dy(III) enantiomers showing single-ion magnet and ferroelectric properties
Leah Pandiscia, PhD
August 13, 2018