The Gram-negative bacterium Aggregatibacter actinomycetemcomitans, commonly associated with localized aggressive periodontitis (LAP), secretes an RTX (repeats-in-toxin) protein leukotoxin (LtxA) that targets… Continue reading Receptor-Based Peptides for Inhibition of Leukotoxin Activity
Leah Pandiscia, PhD
August 13, 2018
Thioflavin T (ThT) was once regarded to be a specific fluorescent probe for the human telomeric G-quadruplex, but more other… Continue reading Lighting Up the Thioflavin T by Parallel-Stranded TG(GA)n DNA Homoduplexes
Leah Pandiscia, PhD
August 13, 2018
Broad-spectrum antibiotics indiscriminately kill bacteria, removing nonpathogenic microorganisms and leading to evolution of antibiotic resistant strains. Specific antimicrobials that could… Continue reading Selective Killing of Pathogenic Bacteria by Antimicrobial Silver Nanoparticle—Cell Wall Binding Domain Conjugates
Leah Pandiscia, PhD
August 13, 2018
The enantioselective synthesis of azahelicenes and S-shaped double azahelicenes has been achieved via the Au-catalyzed sequential intramolecular hydroarylation of alkynes.… Continue reading Enantioselective Synthesis and Enhanced Circularly Polarized Luminescence of S-Shaped Double Azahelicenes
Leah Pandiscia, PhD
August 13, 2018
Chiral boron dipyrromethenes (BPs) enjoy high fluorescence efficiency at visible to near-IR wavelength regions with a reasonable range of dissymmetry… Continue reading Propeller Chirality of Boron Heptaaryldipyrromethene: Unprecedented Supramolecular Dimerization and Chiroptical Properties
Leah Pandiscia, PhD
August 13, 2018
Herein we describe the synthesis, structure, and properties of chiral peropyrenes. Using p-terphenyl-2,2″,6,6″-tetrayne derivatives as precursors, chiral peropyrenes were formed after… Continue reading Chiral Peropyrene: Synthesis, Structure, and Properties
Leah Pandiscia, PhD
August 13, 2018
To isolate putative lipase enzymes by screening a Cerrado soil metagenomic library with novel features. Of 6720 clones evaluated, Clone… Continue reading Structural and functional characterization of a novel lipolytic enzyme from a Brazilian Cerrado soil metagenomic library
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Binding interaction of Bovine Serum Albumin (BSA) with newly prepared rhodamine 6G-capped gold nanoparticles (Rh6G-Au NPs) under physiological conditions (pH 7.2)… Continue reading Multispectroscopic and bioimaging approach for the interaction of rhodamine 6G capped gold nanoparticles with bovine serum albumin
Leah Pandiscia, PhD
August 13, 2018
Integrin-linked kinase (ILK) is a ubiquitously expressed Ser/Thr kinase which plays significant role in the cell-matrix interactions and growth factor… Continue reading Unravelling the unfolding mechanism of human integrin linked kinase by GdmCl-induced denaturation
Leah Pandiscia, PhD
August 13, 2018
Here, we report a fluorescent sensor for the detection of Ce(III) using di-naphthoylated oxacalix[4]arene (DNOC). Formation of the DNOC-Ce(III) complex… Continue reading Sensing of Ce(III) using di-naphthoylated oxacalix[4]arene via realistic simulations and experimental studies
Leah Pandiscia, PhD
August 13, 2018
Thiolate coordination to zinc(II) ions occurs widely in such functional biomolecules as zinc enzymes or zinc finger proteins. Here, we… Continue reading A simple method for determining the ligand affinity toward a zinc-enzyme model by using a TAMRA/TAMRA interaction
Leah Pandiscia, PhD
August 13, 2018
Papillomavirus oncoprotein E6 is a critical factor in the modulation of cervical cancer in humans. At the molecular level, formation… Continue reading A Cu2+ complex induces the aggregation of human papillomavirus oncoprotein E6 and stabilizes p53
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Polymer-based nanotheranostics for cancer treatment and diagnosis are appealing tools in the fast-growing field of nanomedicine. In this paper, we… Continue reading PEI-NIR Heptamethine Cyanine Nanotheranostics for Tumor Targeted Gene Delivery
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018
Leah Pandiscia, PhD
August 13, 2018