Deposition of amyloid fibrils consisting of amyloid β (Aβ) protein as senile plaques in the brain is a pathological hallmark… Continue reading Key residues for the oligomerization of Aβ42 protein in Alzheimer’s disease
Leah Pandiscia, PhD
May 22, 2018
Introduction: Lead exposure can cause learning disabilities, memory loss and severe damage to the nervous system. However, the exact mechanism by… Continue reading Novel approach for generation of low calcium reagents for investigations of heavy metal effects on calcium signaling
Leah Pandiscia, PhD
May 22, 2018
Phosphomevalonate kinase (PMK) phosphorylates mevalonate-5-phosphate (M5P) in the mevalonate pathway, which is the sole source of isoprenoids and steroids in… Continue reading Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase
Leah Pandiscia, PhD
May 22, 2018
We have previously discovered the tubulin-binding anti-cancer properties of noscapine and its derivatives (noscapinoids). Here, we present three lines of… Continue reading Molecular modelling and competition binding study of Br-noscapine and colchicine provide insight into noscapinoid–tubulin binding site
Leah Pandiscia, PhD
May 22, 2018
The synthesis and characterization of a new segmented alternating copolymer is described, having monodisperse, partially methoxy-substituted bis-1,4-styrylbenzene chromophores linked with… Continue reading A water-solubilized, segmented, alternating block copolymer of a 1,4-bis-styrylbenzene with polyethylene glycol
Leah Pandiscia, PhD
May 22, 2018
Commercial isolated pea protein dispersion (IPP, 1%, w/v) was pretreated with high pressure (200–600 MPa, 5 min at 24 °C) or heat (100 °C,… Continue reading Effect of pressure or temperature pretreatment of isolated pea protein on properties of the enzymatic hydrolysates
Leah Pandiscia, PhD
May 22, 2018
Development of simple, sensitive, and rapid method for cocaine detection is important in medicine and drug abuse monitoring. Taking advantage… Continue reading Direct fluorescence anisotropy assay for cocaine using
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
This paper evaluates the spectroscopic properties of the Erbium (Er3+) ions doped magnesium zinc sulfophosphate glass system synthesized via melt-quenching… Continue reading Spectral characteristics of Er3+ doped magnesium zinc sulfophosphate glasses
Leah Pandiscia, PhD
May 22, 2018
An advanced site-specific conjugation strategy for the preparation of quantum dot-based antibody probes applicable in various immunoassays from fluorescence to… Continue reading An advanced conjugation strategy for the preparation of quantum dot-antibody immunoprobes
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Binding studies between a multi-targeted anticancer drug, sunitinib (SU) and human serum albumin (HSA) were made using fluorescence, UV-vis absorption,… Continue reading Comprehensive insight into the binding of sunitinib, a multi-targeted anticancer drug to human serum albumin
Leah Pandiscia, PhD
May 22, 2018
A simple colorimetric fluorescent chemosensor 1-[5-(2-chloro-6-methylquinolin-3-yl)-3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethan-1-one (L) based on pyrazoline has been designed, synthesized and characterized. The sensing properties of L were… Continue reading New pyrazolo-quinoline scaffold as a reversible colorimetric fluorescent probe for selective detection of Zn2+ ions and its imaging in live cells
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The photophysical properties of o-tolyl-, m-tolyl-, and p-xylyl-substituted asymmetric diaroylmethanatoboron difluorides in a mixture of CH2Cl2 and c-C6H12, and in the crystalline state were determined.… Continue reading Cooperative Effects of o- and m-Methyl Groups on the Intramolecular Charge-Transfer Emission Properties of Dibenzoylmethanatoboron Difluorides
Leah Pandiscia, PhD
May 22, 2018
In this study, the potential of using fluorescence fingerprint, also known as fluorescence excitation–emission matrix, for estimating the scavenging capacity… Continue reading Simultaneous estimation of scavenging capacities of peach extract for multiple reactive oxygen species by fluorescence fingerprint method
Leah Pandiscia, PhD
May 22, 2018
1-(Silylethynyl)naphthalenes (1a-e) and 1,4-bis(silylethynyl)naphthalenes (2a-c) were prepared, and their fluorescence properties were evaluated in solutions, thin films and solid states.… Continue reading Fluorescence properties of 1-(silylethynyl)naphthalenes and 1,4-bis(silylethynyl)naphthalenes in solutions, thin films and solid states
Leah Pandiscia, PhD
May 22, 2018
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to… Continue reading Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus
Leah Pandiscia, PhD
May 22, 2018
The selective chemosensing behaviour of imidazole bisthiocarbohydrazone (IBTC) towards F− and Cu2 + are studied via colorimetric, UV–Visible, fluorescence spectra studies, and binding constants were… Continue reading Multi-ion detection and molecular switching behaviour of reversible dual fluorescent sensor
Leah Pandiscia, PhD
May 22, 2018