Herein, a series of azobenzene (Azo)-containing side-chain cyclic polymers were successfully synthesized by combining atom transfer radical polymerization (ATRP) and… Continue reading Supramolecular chirality induced by chiral solvation in achiral cyclic Azo-containing polymers: topological effects on chiral aggregation
Leah Pandiscia, PhD
May 22, 2018
The parasitoid wasp Ampulex compressa injects venom directly into the brain and subesophageal ganglion of the cockroach Periplaneta americana, inducing… Continue reading Ampulexins: A New Family of Peptides in Venom of the Emerald Jewel Wasp, Ampulex compressa
Leah Pandiscia, PhD
May 22, 2018
(±)-Sativamides A (1) and B (2), two pairs of nor-lignanamide enantiomers featuring a unique benzo-angular triquinane skeleton, were isolated from… Continue reading (±)-Sativamides A and B, Two Pairs of Racemic Nor-Lignanamide Enantiomers from the Fruits of Cannabis sativa
Leah Pandiscia, PhD
May 22, 2018
Proteins that fold as (β/α)8 barrels are thought to have evolved from half-barrels that underwent duplication and fusion events. The evidence… Continue reading Search for independent (β/α)4 subdomains in a (β/α)8 barrel β-glucosidase
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The specialized, fungal pathogen Escovopsis weberi threatens the mutualistic symbiosis between leaf-cutting ants and their garden fungus (Leucoagaricus gongylophorus). Because E. weberi can overwhelm L.… Continue reading Secondary Metabolites from Escovopsis weberi and Their Role in Attacking the Garden Fungus of Leaf-Cutting Ants
Leah Pandiscia, PhD
May 22, 2018
Novel fluorescent monometallic Ag nanohybrids (Ag NHs) have been synthesized viapolycytosine-mediated biomineralization on Ag nanoparticles (Ag NPs). Thiolated polycytosine dC12 was anchored… Continue reading Fabrication of multifunctional monometallic nanohybrids for reactive oxygen species-mediated cell apoptosis and enhanced fluorescence cell imaging
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Amyotrophic lateral sclerosis (ALS) involves the abnormal posttranslational modifications and fibrillization of copper, zinc superoxide dismutase (SOD1) and TDP-43. However,… Continue reading Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111
Leah Pandiscia, PhD
May 22, 2018
Phototropin is a blue light sensor protein found in higher plants and green algae. Photochemical reactions of a variety of… Continue reading Photoreaction Dynamics of LOV1 and LOV2 of Phototropin from Chlamydomonas reinhardtii
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Designing peptide-based drugs to target the β-sheet-rich toxic intermediates during the aggregation of amyloid-β 1-42 (Aβ1-42) has been a major… Continue reading Inhibition of β-Amyloid Aggregation through a Designed β-Hairpin Peptide
Leah Pandiscia, PhD
May 22, 2018
Stress granules are non-membranous structures that transiently form in the cytoplasm during cellular stress, where they promote translational repression of non-essential… Continue reading TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn2+
Leah Pandiscia, PhD
May 22, 2018
Creating and establishing proof of hybrid protein nanofibers (hPNFs), i.e., PNFs that contain more than one protein, is a currently unsolved… Continue reading Protein Handshake on the Nanoscale: How Albumin and Hemoglobin Self-Assemble into Nanohybrid Fibers
Leah Pandiscia, PhD
May 22, 2018
Fluorescence detection typically enhances sensitivity and selectivity for fluorescent analytes. The potential for combining fluorescence detection with flow orientation of… Continue reading Fluorescence detected linear dichroism spectroscopy: A selective and sensitive probe for fluorophores in flow-oriented systems
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Neurotensin (NTS)-polyplex is a nanoparticle system for targeted gene delivery that holds great promise for treatment of Parkinson’s disease and… Continue reading Development of a Parenteral Formulation of NTS-Polyplex Nanoparticles for Clinical Purpose
Leah Pandiscia, PhD
May 22, 2018
The effect of a potent antimicrobial compound bearing 1,2,3-triazole core and a tryptophan tail, triazole-tryptophan hybrid (TTH), with bovine serum… Continue reading Effect of triazole-tryptophan hybrid on the conformation stability of bovine serum albumin
Leah Pandiscia, PhD
May 22, 2018
Staphylokinase (SAK) is a profibrinolytic protein and can be used for therapy of acute myocardial infarction and coronary thrombosis. However,… Continue reading Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018