In aqueous solutions, an elongated, negatively charged DNA chain can quickly change its conformation into a compacted globule in the… Continue reading Investigation of compacted DNA structures induced by Na+ and K+monovalent cations using biological nanopores
Leah Pandiscia, PhD
May 22, 2018
Polychlorinated biphenyls (PCBs) are harmful and persistent organic pollutants that have long been used in industrial manufacturing. Their persistence leads… Continue reading Enantioseparation and identification for the rationalization of the environmental impact of 4 polychlorinated biphenyls
Leah Pandiscia, PhD
May 22, 2018
In biological systems, there are many signal transduction cascades in which a chemical signal is transferred as a series of… Continue reading Response speed control of helicity inversion based on a “regulatory enzyme”-like strategy
Leah Pandiscia, PhD
May 22, 2018
Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure was established by spectroscopic analysis,… Continue reading A Tri-O-Bridged Diels-Alder Adduct from Cortex Mori Radicis
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Sequence and structural homology suggests that MP-4 protein from Mucuna pruriens belongs to Kunitz-type protease inhibitor family. However, biochemical assays showed that… Continue reading Docking, thermodynamics and molecular dynamics (MD) studies of a non-canonical protease inhibitor, MP-4, from Mucuna pruriens
Leah Pandiscia, PhD
May 22, 2018
Molecular tools to stabilize the β-hairpin conformation are needed as β-hairpin peptides are useful molecules for pharmaceutical, biological and materials… Continue reading Conformational stabilization of a β-hairpin through a triazole–tryptophan interaction
Leah Pandiscia, PhD
May 22, 2018
A minimal model system for membrane fusion, comprising two complementary peptides dubbed “E” and “K” joined to a cholesterol anchor… Continue reading Peptide-Mediated Liposome Fusion: The Effect of Anchor Positioning
Leah Pandiscia, PhD
May 22, 2018
Seven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures,… Continue reading Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279
Leah Pandiscia, PhD
May 22, 2018
Insulin-like peptide 3 (INSL3) is a member of the relaxin/insulin superfamily and is expressed in testicular Leydig cells. Essential for… Continue reading Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity
Leah Pandiscia, PhD
May 22, 2018
Glutathione S‒transferases (GSTs) play an important role in the detoxification of xenobiotics. They catalyze the nucleophilic addition of glutathione (GSH)… Continue reading Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica
Leah Pandiscia, PhD
May 22, 2018
Assembly of fibrillar peptide structures is dependent both upon their intrinsic propensities toward β-structure formation, as well as on structural… Continue reading Membrane Determinants Affect Fibrillation Processes of β-Sheet Charged Peptides
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
A methanolic extract of Morella salicifolia bark was fractionated by various chromatographic techniques yielding six previously unknown cyclic diarylheptanoids, namely, 7-hydroxymyricanol 5-O-β-d-glucopyranoside… Continue reading Diarylheptanoid Glycosides of Morella salicifolia Bark
Leah Pandiscia, PhD
May 22, 2018
The dynamics and mechanism of how site-specific DNA-bending proteins initially interrogate potential binding sites prior to recognition have remained elusive… Continue reading Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018