Factor H (FH) is a key alternative pathway regulator that controls complement activation both in the fluid phase and on… Continue reading Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins
Leah Pandiscia, PhD
May 22, 2018
Beclin-1 (BECN1) is an essential component of macroautophagy. This process is a highly conserved survival mechanism that recycles damaged cellular… Continue reading The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity
Leah Pandiscia, PhD
May 22, 2018
Light chain amyloidosis (AL), the most common systemic amyloidosis, is caused by the overproduction and the aggregation of monoclonal immunoglobulin… Continue reading Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity
Leah Pandiscia, PhD
May 22, 2018
Biomimetic organization provides a promising strategy to develop functional materials and understand biological processes. However, how to mimic complex biological… Continue reading Biomimetic Oxygen-Evolving Photobacteria Based on Amino Acid and Porphyrin Hierarchical Self-Organization
Leah Pandiscia, PhD
May 22, 2018
The effect of the side chain chiral center position on the secondary structure of oligomers and polymers of N-substituted 4-aminobenzoic acid… Continue reading Effect of the α-substituted chiral side chain on the helical conformation of N-substituted poly(p-benzamide)
Leah Pandiscia, PhD
May 22, 2018
The receptor for the urokinase-type plasminogen activator (uPAR) is a widely recognized master regulator of cell migration. We and others have previously documented… Continue reading Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration
Leah Pandiscia, PhD
May 22, 2018
In the present study, the neuroprotective effects of Chinese bayberry leaves proanthocyanidin (BLPs) were investigated by targeting at Aβ fibrillization… Continue reading The neuroprotective effects of Chinese bayberry leaves proanthocyanidins
Leah Pandiscia, PhD
May 22, 2018
Giardiasis, the infestation of the intestinal tract by Giardia lamblia, is one of the most prevalent parasitosis worldwide. Even though effective… Continue reading Disulfiram as a novel inactivator of Giardia lambliatriosephosphate isomerase with antigiardial potential
Leah Pandiscia, PhD
May 22, 2018
In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the… Continue reading Bioactive Compounds from the Stems of Clausena lansium
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Given the potential of productive interaction between choline-based amino acid ionic liquids (CAAILs) and collagen, we investigated the role of… Continue reading Choline-Based Amino Acid ILs–Collagen Interaction: Enunciating Its Role in Stabilization/Destabilization Phenomena
Leah Pandiscia, PhD
May 22, 2018
Human dihydroorotate dehydrogenase (HsDHODH) enzyme has been studied as selective target for inhibitors to block the enzyme activity, intending to… Continue reading HsDHODH Microdomain–Membrane Interactions Influenced by the Lipid Composition
Leah Pandiscia, PhD
May 22, 2018
Intrinsically disordered (ID) regions of the transcription factor proteins have much larger frequency of phosphorylation sites than ordered regions, suggesting… Continue reading Site-specific phosphorylation regulates the structure and function of an intrinsically disordered domain of the glucocorticoid receptor
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Helical structures at different scales endow functional materials with special optical, electrical, and magnetic properties. However, methods for constructing and… Continue reading Self-Assembled 3D Helical Hollow Superstructures with Enhanced Microwave Absorption Properties
Leah Pandiscia, PhD
May 22, 2018
We have reported the interaction of two flavonoids namely quercetin (Q) and morin (M) with double stranded poly(A).poly(U) (herein after A.U) and triple stranded… Continue reading Role of hydroxyl groups in the B-ring of flavonoids in stabilization of the Hoogsteen paired third strand of Poly(U).Poly(A)*Poly(U) triplex
Leah Pandiscia, PhD
May 22, 2018
Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of JAK proteins that are receptor-associated tyrosine kinases, which play key… Continue reading Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1
Leah Pandiscia, PhD
May 22, 2018
Seven new phloroglucinol derivatives, myrtucommunins A–D (1–4), 6-methylisomyrtucommulone B (5), 4-methylmyrtucommulone B (6), and 2-isobutyryl-4-methylphloroglucinol 1-O-β-d-glucopyranoside (7), and one new… Continue reading Phloroglucinol derivatives and a chromone glucoside from the leaves of Myrtus communis
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Three new tirucallane-type triterpenes named boscartene L–N (1–3) and three known compounds (4–6) were isolated from the gum resin of Boswellia… Continue reading Isolation, characterization, and hepatoprotective activities of terpenes from the gum resin of Boswellia carterii Birdw
Leah Pandiscia, PhD
May 22, 2018