Luminol, horseradish peroxidase (HRP), and glucose oxidase (GOx) ternary functionalized graphene oxide (HRP/GOx-luminol-GO) with excellent chemiluminescence (CL) activity and specific… Continue reading Luminol, horseradish peroxidase, and glucose oxidase ternary functionalized graphene oxide for ultrasensitive glucose sensing
Leah Pandiscia, PhD
May 22, 2018
Previously, we demonstrated that binding of a ligand to Escherichia coli cofactor-dependent phosphoglycerate mutase (dPGM), a homodimeric protein, is energetically coupled with… Continue reading A Cooperative Folding Unit as the Structural Link for Energetic Coupling within a Protein
Leah Pandiscia, PhD
May 22, 2018
The chiral recognition of racemic α-hydroxy/amino acids is an essential and challenging mission because enantiomers may profoundly differ in biological… Continue reading Chiral metal–organic frameworks constructed from four-fold helical chain SBUs for enantioselective recognition of α-hydroxy/amino acids
Leah Pandiscia, PhD
May 22, 2018
There are many biotechnology applications that would benefit from simple, stable proteins with engineered biomolecular recognition. Here, we explored the… Continue reading Engineered Biomolecular Recognition of RDX by Using a Thermostable Alcohol Dehydrogenase as a Protein Scaffold
Leah Pandiscia, PhD
May 22, 2018
The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer’s disease. Although Tau interaction with membranes is… Continue reading Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes
Leah Pandiscia, PhD
May 22, 2018
The presence of anomalous chirality in a roll of graphitic carbon sheets has been recognized since the discovery of carbon… Continue reading Chiral intertwined spirals and magnetic transition dipole moments dictated by cylinder helicity
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Chiral properties of surface complexes based on CdSe/ZnS quantum dots (QDs) and 1-(2-pyridylazo)-2-naphthol (PAN) azo dye were investigated by circular… Continue reading Circular dichroism of surface complexes based on quantum dots and azo dye
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Recently, a 3-hydroxychromone based nucleoside 3HCnt has been developed as a highly environment-sensitive nucleoside surrogate to investigate protein–DNA interactions. When… Continue reading Structural and Dynamical Impact of a Universal Fluorescent Nucleoside Analogue Inserted Into a DNA Duplex
Leah Pandiscia, PhD
May 22, 2018
Proteins predicted to be composed of large stretches of coiled-coil structure have often proven difficult to crystallize for structural determination.… Continue reading Production of recombinant human tektin 1, 2, and 4 and in vitro assembly of human tektin 1
Leah Pandiscia, PhD
May 22, 2018
A phytochemical investigation on the aerial part of Euphorbia helioscopia(Euphorbiaceae) led to the isolation of 22 highly oxygenated diterpenoids with structural types of ent-abietane, ent-kaurane,… Continue reading Highly oxygenated and structurally diverse diterpenoids from Euphorbia helioscopia
Leah Pandiscia, PhD
May 22, 2018
Human flavin-containing monooxygenase 3 (hFMO3) catalyses the oxygenation of a wide variety of compounds including drugs as well as dietary… Continue reading Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine
Leah Pandiscia, PhD
May 22, 2018
Polymeric nanoparticles based on cyclodextrins are currently undergoing clinical trials as new promising nanotherapeutics. In light of this interest, we… Continue reading Cyclodextrin polymers as nanocarriers for sorafenib
Leah Pandiscia, PhD
May 22, 2018
Plants adapt to fluctuating light conditions by a process called non-photochemical quenching (NPQ), where membrane protein PsbS plays a crucial… Continue reading Large-scale in vitro production, refolding and dimerization of PsbS in different microenvironments
Leah Pandiscia, PhD
May 22, 2018
Spinocerebellar ataxia type 5 (SCA5) is a neurodegenerative disease caused by mutations in the cytoskeletal protein β-III-spectrin. Previously, a SCA5… Continue reading Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Cell-penetrating peptides (CPPs) have been applied as novel transport systems with the ability to facilitate the delivery of peptides, proteins,… Continue reading OBP fused with cell-penetrating peptides promotes liposomal transduction
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018