Examples of bioactive peptides derived from internal sequences of proteins are known for decades. The great majority of these findings… Continue reading Encrypted Antimicrobial Peptides from Plant Proteins
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
A novel series of indole and benzimidazole bichalcophene diamidine derivatives were prepared to study their antimicrobial activity against the tropical… Continue reading Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
In recent years, ionic liquids and enzymes have been widely used in the separation and extraction processes of natural products.… Continue reading Ionic liquid-based enzyme-assisted extraction of chlorogenic acid from Flos Lonicera Japonicae
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Interaction of two mononuclear tetracoordinate complexes [Co(dmphen)Br2] and [Co(dmphen)I2] (dmphen = 2,9-dimethyl-1,10-phenanthroline), which have been recently reported to behave as single-molecule magnets… Continue reading Tetracoordinate cobalt(II) complexes with neocuproine: single-molecule magnets with potential biological activity
Leah Pandiscia, PhD
May 22, 2018
A series of new β-carboline-bisindole compounds were designed, synthesized and evaluated for their antiproliferative activity against human cancer cell lines, such as A549… Continue reading Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors
Leah Pandiscia, PhD
May 22, 2018
G-quadruplexes (G4) within oncogene promoters are considered to be promising anticancer targets. However, often they undergo complex structural rearrangements that… Continue reading Conformational profiling of a G-rich sequence within the c-KIT promoter
Leah Pandiscia, PhD
May 22, 2018
Because uncontrolled accumulation of collagen fibrils has been implicated in a series of pathologies, inhibition of collagen fibril formation has… Continue reading Strategically Designed Antifibrotic Gold Nanoparticles to Prevent Collagen Fibril Formation
Leah Pandiscia, PhD
May 22, 2018
Seven new phloroglucinol derivatives, uraliones L-R (1–7), were isolated from the whole plant of Hypericum urialum. The structures of new compounds… Continue reading New phloroglucinol derivatives from the whole plant of Hypericum uralum
Leah Pandiscia, PhD
May 22, 2018
Intrinsic disorder is a major structural category in biology, accounting for more than 30% of coding regions across the domains… Continue reading Hidden Structural Codes in Protein Intrinsic Disorder
Leah Pandiscia, PhD
May 22, 2018
Onconase® (ONC), extracted by the oocytes of the frog Rana Pipiens , is a monomeric member of the secretory “pancreatic-type” RNase super-family.… Continue reading Onconase Dimerization Through 3D Domain Swapping: Structural Investigations and Increase Of The Apoptotic Effect In Cancer Cells
Leah Pandiscia, PhD
May 22, 2018
For the first time, the photoisomerization of a diarylethene moiety (DAET) in peptideconjugates was used to probe the effects of molecular… Continue reading Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers
Leah Pandiscia, PhD
May 22, 2018
Calmodulin (CaM) is an intracellular Ca2+ transducer involved in numerous activities in a broad Ca2+signaling network. Previous studies have suggested that… Continue reading Direct Visualization of Interaction between Calmodulin and Connexin45
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Kisspeptin 1 is a neuropeptide hormone of the RFamide family, which act as an upstream regulator of brain-pituitary-gonad (BPG) axis… Continue reading Conformational analysis of a synthetic fish kisspeptin 1 peptide in membrane mimicking environments
Leah Pandiscia, PhD
May 22, 2018
A series of discotic tricarboxyamides with varied amino acid side arm functionality and their HCl responsive diverse self-assembly behavior and… Continue reading Dynamic self-assembled polymer: HCl responsive inversion of supramolecular polymer handedness
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018