In the present work, the interaction of Isoxsuprine (ISX) with Calf thymus DNA (ct-DNA) under physiological conditions (Tris–HCl buffer of… Continue reading Binding Studies of Isoxsuprine Hydrochloride to Calf Thymus DNA Using Multispectroscopic and Molecular Docking Techniques
Leah Pandiscia, PhD
May 22, 2018
Cephalosporins belong the largest class of antibiotics used in the treatment of a wide range of infectious diseases caused by… Continue reading Probing the interaction of cephalosporin with bovine serum albumin: A structural and comparative perspective
Leah Pandiscia, PhD
May 22, 2018
Two anticancer gold(III) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively… Continue reading Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells
Leah Pandiscia, PhD
May 22, 2018
Herein we discuss the differential interaction of three monosubstituted fullerene derivatives possessing pyridinium, aniline or phenothiazine end groups (F-Py, F-An and F-PTz, respectively)… Continue reading Chiral self-assembly of fullerene clusters on CT-DNA templates
Leah Pandiscia, PhD
May 22, 2018
Stable tissue integrity during embryonic development relies on the function of the cadherin·catenin complex (CCC). The Caenorhabditis elegans CCC is a useful… Continue reading Cell–cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β-catenin–binding interface
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Affitins are highly stable engineered affinity proteins, originally derived from Sac7d and Sso7d, two 7 kDa DNA-binding polypeptides from Sulfolobus genera. Their efficiency… Continue reading A novel, smaller scaffold for Affitins: Showcase with binders specific for EpCAM
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Thirty-three metabolites including five phenalenone derivatives (1–5), seven cytochalasins (6–12), thirteen butenolides (13–25), and eight phenyl derivatives (26–33) were isolated… Continue reading Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities
Leah Pandiscia, PhD
May 22, 2018
Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of… Continue reading Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan
Leah Pandiscia, PhD
May 22, 2018
Saffron, a spice from Crocus sativus, has been known for its health benefits and medicinal properties. Safranal is a component of… Continue reading Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
IR spectroscopy was used to probe the composition of the freeze concentrated liquid (FCL) during near equilibrium freezing of albumin–dimethyl… Continue reading Effect of high DMSO concentration on albumin during freezing and vitrification
Leah Pandiscia, PhD
May 22, 2018
Nanoparticles composed of functional materials hold great promise for applications due to their unique electronic, optical, magnetic, and catalytic properties.… Continue reading Corrosion-Protected Hybrid Nanoparticles
Leah Pandiscia, PhD
May 22, 2018
Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype. The high rate of metastasis associated to the fact… Continue reading Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells
Leah Pandiscia, PhD
May 22, 2018
The aggregation of amyloid-β peptide (Aβ) is implicated in the pathology of Alzheimer’s disease (AD), and Aβ oligomers are considered… Continue reading Rational design of a “sense and treat” system to target amyloid aggregates related to Alzheimer’s disease
Leah Pandiscia, PhD
May 22, 2018
A pair of optically pure triptycene derivatives ((R,R)- and (S,S)-3) containing fluorescent pyrene-based π-conjugated pendant groups attached through amide spacers… Continue reading Chiral triptycene-pyrene π-conjugated chromophores with circularly polarized luminescence
Leah Pandiscia, PhD
May 22, 2018
The molecular origin behind the concentration-dependent intrinsic blue fluorescence of human serum albumin (HSA) is not known yet. This unusual… Continue reading Direct Evidence of Intrinsic Blue Fluorescence from Oligomeric Interfaces of Human Serum Albumin
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Symmetry breaking of single-walled carbon nanotubes (SWNTs) has profound effects on their optoelectronic properties that are essential for fundamental study… Continue reading Determination of the Absolute Enantiomeric Excess of the Carbon Nanotube Ensemble by Symmetry Breaking Using the Optical Titration Method
Leah Pandiscia, PhD
May 22, 2018