Supramolecular chirality is achieved in amphiphilic block copolymer films made through two-step fabrication: self-assembling first and then solution coating. The… Continue reading Supramolecular chirality of amphiphilic block copolymer films made through two steps: self-assembling first, and then solution coating
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The handedness of the self-assemblies of several series of homogeneous lipodipeptide sodium salts is controlled by the chirality of the… Continue reading Molecular packing and the handedness of the self-assemblies of C17H35CO-Ala-Phe sodium salts
Leah Pandiscia, PhD
May 22, 2018
The antibody Fv module which binds antigen consists of the variable domains VL and VH. These exhibit a conserved ß-sheet structure… Continue reading Determinants of the assembly and function of antibody variable domains
Leah Pandiscia, PhD
May 22, 2018
The binding modes of a pyrene–porphyrin dyad, (1-pyrenyl)-tris(N-methyl-p-pyridino)porphyrin (PyTMpyP), to DNA and its photophysical properties have been investigated using various… Continue reading Relationship between the photoinduced electron transfer and binding modes of a pyrene–porphyrin dyad to DNA
Leah Pandiscia, PhD
May 22, 2018
Increasing bacterial resistance towards antibiotics has stimulated research for novel antimicrobials. Proteins acting on bacterial membranes could be a solution.… Continue reading Antimicrobial activity of lysozyme isoforms: Key molecular features
Leah Pandiscia, PhD
May 22, 2018
Rational design of prodrugs for efficient albumin binding shows distinct advantages in drug delivery in terms of drug availability, systemic… Continue reading Regulating the alky chain length of fatty acid-didanosine prodrugs and evaluating its role in albumin binding
Leah Pandiscia, PhD
May 22, 2018
Henipaviruses are severe human pathogens within the Paramyxoviridae family. Beyond the P protein, the Henipavirus P gene also encodes the V protein which shares… Continue reading The Henipavirus V protein is a prevalently unfolded protein with a zinc-finger domain involved in binding to DDB1
Leah Pandiscia, PhD
May 22, 2018
Gold nanorods (GNRs) are a unique class of metal nanostructures that have attractive potentials in biomedical applications, and the concern… Continue reading Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes
Leah Pandiscia, PhD
May 22, 2018
For the purpose of improving the tumor delivery of doxorubicin (DOX), a kind of peptide-DOXO conjugate was designed and prepared,… Continue reading Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin
Leah Pandiscia, PhD
May 22, 2018
Calcium (Cav1 and Cav2) and sodium channels possess homologous CaM-binding motifs, known as IQ motifs in their C termini, which… Continue reading Calmodulin regulates Cav3 T-type channels at their gating brake
Leah Pandiscia, PhD
May 22, 2018
Hydrophobins (HFBs) are small surface-active proteins secreted by filamentous fungi. Being amphiphilic, they spontaneously form layers that convert surfaces from… Continue reading COMPARATIVE PHYSIOCHEMICAL ANALYSIS OF HYDROPHOBINS PRODUCED IN ESCHERICHIA COLIAND PICHIA PASTORIS
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
α-Helical peptides are known as efficient mediators of electron transfer; however, their use is limited to compounds longer that 7–10… Continue reading α-Helicomimetic foldamers as electron transfer mediators
Leah Pandiscia, PhD
May 22, 2018
Boron clusters are polyhedral boron hydrides with unique properties, and they are becoming increasingly widely used in biology and medicine,… Continue reading Interactions of Boron Clusters and their Derivatives with Serum Albumin
Leah Pandiscia, PhD
May 22, 2018
Among various techniques of immobilization, EDC/NHS cross linking is a simple and single step process for covalent coupling between enzymes… Continue reading Facile fabrication of lipase to amine functionalized gold nanoparticles to enhance stability and activity
Leah Pandiscia, PhD
May 22, 2018
The ligand-induced conformational changes of periplasmic binding proteins (PBP) play a key role in the acquisition of metabolites in ATP… Continue reading Periplasmic Binding Protein Dimer Has a Second Allosteric Event Tied to Ligand Binding
Leah Pandiscia, PhD
May 22, 2018
A decrease in the specific activity of an enzyme is commonly observed when the enzyme is inappropriately handled or is… Continue reading An activity transition from NADH dehydrogenase to NADH oxidase during protein denaturation
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Biotherapeutics such as monoclonal antibodies (mAbs) have a major share of the pharmaceutical industry for treatment of life-threatening chronic diseases… Continue reading Peptide Dendrons as Thermal-Stability Amplifiers for Immunoglobulin G1 Monoclonal Antibody Biotherapeutics
Leah Pandiscia, PhD
May 22, 2018