Selenium (Se) nanoparticles (NPs) have attracted significant interest in biological and biomedical applications due to their therapeutic efficacy. For any in… Continue reading Elucidating the interaction of L-cysteine-capped selenium nanoparticles and human serum albumin: spectroscopic and thermodynamic analysis
Leah Pandiscia, PhD
May 22, 2018
Peptides containing aromatic residues are known to exhibit spontaneous phenomena of supramolecular organization into ordered nanostructures (NSs). In this work… Continue reading Structural Characterization of PEGylated Hexaphenylalanine Nanostructures Exhibiting Green Photoluminescence Emission
Leah Pandiscia, PhD
May 22, 2018
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly successful human pathogen and has infected approximately one-third of… Continue reading Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosisIs Controlled by a Redox-Sensitive Thiol Switch
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Hypochlorous acid (HOCl) is generated by activated phagocytes at the site of inflammation. Exposure of DNA to HOCl results in base and nucleotide modifications… Continue reading Hypochlorous acid induced structural and conformational modifications in human DNA: A multi-spectroscopic study
Leah Pandiscia, PhD
May 22, 2018
Linear cationic α-helical antimicrobial peptides are promising chemotherapeutics. Most of them act by different mechanisms, making it difficult to microorganisms… Continue reading Antimicrobial activity of leucine-substituted decoralin analogs with lower hemolytic activity
Leah Pandiscia, PhD
May 22, 2018
Self-assembling fibrous supramolecular assemblies with sophisticated hierarchical structures at the mesoscale are of interest from both fundamental and applied engineering.… Continue reading Self-Assembling Silk-Based Nanofibers with Hierarchical Structures
Leah Pandiscia, PhD
May 22, 2018
3-Ethyl-3-phenylpyrrolidin-2-one (EPP) is an experimental anticonvulsant based on the newly proposed α-substituted amide group pharmacophore. These compounds show robust activity in… Continue reading Racemic and enantiopure forms of 3-ethyl-3-phenylpyrrolidin-2-one adopt very different crystal structures
Leah Pandiscia, PhD
May 22, 2018
Recombinantly produced spider silk proteins have high potential for bioengineering and various biomedical applications because of their biocompatibility, biodegradability, and… Continue reading Characterization of Hydrogels Made of a Novel Spider Silk Protein eMaSp1s and Evaluation for 3D Printing
Leah Pandiscia, PhD
May 22, 2018
There are many important diseases whose treatment could be improved by delivering a therapeutic protein to the colon, for example,… Continue reading A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a Model Protein
Leah Pandiscia, PhD
May 22, 2018
Functional screening of metagenomic libraries is an important tool for the discovery of new molecules. The metabolic diversity of microorganisms… Continue reading Metagenomic alkaline protease from mangrove sediment
Leah Pandiscia, PhD
May 22, 2018
Controlling the hierarchical organization of self-assembling peptide amphiphiles into supramolecular nanostructures opens up the possibility of developing biocompatible functional supramolecular… Continue reading Hierarchical Self-Assembly of Histidine-Functionalized Peptide Amphiphiles into Supramolecular Chiral Nanostructures
Leah Pandiscia, PhD
May 22, 2018
Localized self-assembly allowing both spatial and temporal control over the assembly process is essential in many biological systems. This can… Continue reading Control of Surface-Localized, Enzyme-Assisted Self-Assembly of Peptides through Catalyzed Oligomerization
Leah Pandiscia, PhD
May 22, 2018
When used as inhibitors of gene expression in vivo, oligonucleotides require modification of their structures to boost their binding affinity for… Continue reading Towards Improved Oligonucleotide Therapeutics Through Faster Target Binding Kinetics
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Increasing drug resistance of common pathogens urgently needs discovery of new effective molecules. Antimicrobial peptides are believed to be one… Continue reading Retro analog concept: comparative study on physico-chemical and biological properties of selected antimicrobial peptides
Leah Pandiscia, PhD
May 22, 2018
Physicochemical methods have been used to investigate interactions occurring in solution between the dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)2]BF4 (AuNHC) and a human… Continue reading [Au(9-methylcaffein-8-ylidene)2]+/DNA Tel23 System: Solution, Computational, and Biological Studies
Leah Pandiscia, PhD
May 22, 2018
The characteristic cross-β-sheet-rich amyloid fibril formation by intrinsically disordered α-synuclein proteins is one of the pathological hallmarks of Parkinson’s disease.… Continue reading Perturbation in Long-Range Contacts Modulates the Kinetics of Amyloid Formation in α-Synuclein Familial Mutants
Leah Pandiscia, PhD
May 22, 2018