The chiroptical properties of amorphous chiral polymers functionalized with conjugated trans-azoaromatic chromophore linked to the backbone through a chiral cyclic pyrrolidine… Continue reading Chirality on Amorphous High-Tg Polymeric Nanofilms: Optical Activity Amplification by Thermal Annealing
Leah Pandiscia, PhD
May 22, 2018
The hedgehog (Hh) signaling pathway plays a central role during embryonic development, and its aberrant activation has been implicated in… Continue reading Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The cytoplasmic polyadenylation element binding protein (CPEB) homologue Orb2 is a functional amyloid that plays a key regulatory role for… Continue reading Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2
Leah Pandiscia, PhD
May 22, 2018
Cruzain, a cysteine protease in the cathepsin family, is pivotal to the life-cycle of Trypanosoma cruzi, the etiological agent in Chagas… Continue reading Identification of Structure-Stabilizing Interactions in Enzymes: A Novel Mechanism to Impact Enzyme Activity
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The twisted structure of ditellurides, in a similar way as in other dichalcogenes, leads to different absorption of circularly polarized… Continue reading Chiral dialkyl ditellurides: Conformation of chiral chromophore by circular dichroism and DFT calculation
Leah Pandiscia, PhD
May 22, 2018
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium… Continue reading Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect
Leah Pandiscia, PhD
May 22, 2018
General information about the synthesis and properties of glatiramer acetate (GA) drug substance and the principles and methods for verifying… Continue reading Axoglatiran® FS: Generic of Copaxone® Preparation Based on Glatiramer Acetate
Leah Pandiscia, PhD
May 22, 2018
Cytosine deamination induced by stresses or enzymatic catalysis converts deoxycytidine into deoxyuridine, thereby introducing a G to A mutation after… Continue reading Crystal structure of mimivirus uracil-DNA glycosylase
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
In the past two decades, keratin biomaterials have shown impressive results as scaffolds for tissue engineering, wound healing, and nerve… Continue reading Homo- and heteropolymer self-assembly of recombinant trichocytic keratins
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Many biologically important processes involve a subtle interplay between Columbic and hydrophobic interactions among molecular groups with water. A comprehensive… Continue reading Decisive Role of Hydrophobicity on the Effect of Alkylammonium Chlorides on Protein Stability: A Terahertz Spectroscopic Finding
Leah Pandiscia, PhD
May 22, 2018
Femtosecond (fs)-laser-induced crystallization as a novel crystallization technique was proposed for the first time by our group, where the crystallization… Continue reading Femtosecond-Laser-Enhanced Amyloid Fibril Formation of Insulin
Leah Pandiscia, PhD
May 22, 2018
Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host… Continue reading Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The lectin DLasiL was isolated from seeds of the Dioclea lasiocarpa collected from the northeast coast of Brazil and characterized for the first time… Continue reading The potent anti-cancer activity of Dioclea lasiocarpa lectin
Leah Pandiscia, PhD
May 22, 2018