The self-assembly of amyloidogenic peptides into β-sheet-rich aggregates is a general feature of many neurodegenerative diseases, including Alzheimer’s disease, which… Continue reading Carbon Nanodot-Sensitized Modulation of Alzheimer’s β-Amyloid Self-Assembly, Disassembly, and Toxicity
Leah Pandiscia, PhD
May 22, 2018
PEGylated proteins play an increasingly important role in pharmaceutical drug delivery. We recently showed that short poly(ethylene glycol) (PEG) chains… Continue reading The Surface of Protein λ6–85 Can Act as a Template for Recurring Poly(ethylene glycol) Structure
Leah Pandiscia, PhD
May 22, 2018
The interplay between noncollagenous proteins and biomineralization is widely accepted, yet the contribution of their secondary structure in mineral formation… Continue reading Disordered Conformation with Low Pii Helix in Phosphoproteins Orchestrates Biomimetic Apatite Formation
Leah Pandiscia, PhD
May 22, 2018
The cellular copper level is strictly regulated since excessive copper is harmful to cells. It has been proposed that the… Continue reading Copper-finger protein of Sp1: the molecular basis of copper sensing
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 24, 2018
Leah Pandiscia, PhD
May 22, 2018
Peptide self-assembly has a profound biological significance since self-assembled bioactive peptides are gifted with improved bioactivity as well as life-span.… Continue reading High-Resolution Insights into the Stepwise Self-Assembly of Nanofiber from Bioactive Peptides
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Intrinsically disordered proteins (IDPs) are ubiquitous in eukaryotes, and they are often associated with diseases in humans. The protein NUPR1… Continue reading Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B
Leah Pandiscia, PhD
May 22, 2018
Protein-conjugated CdS nanocrystals (NCs) with different morphology have been synthesized under biomimetic condition using trypsin as capping agent in aqueous… Continue reading Shape-controlled synthesis of protein-conjugated CdS nanocrystals (NCs) and study on the binding of Cd2+/CdS to trypsin
Leah Pandiscia, PhD
May 22, 2018
Self-replication at the molecular level is often seen as essential to the early origins of life. Recently a mechanism of… Continue reading Structural and Spectroscopic Properties of Assemblies of Self-Replicating Peptide Macrocycles
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
The fission yeast Schizosaccharomyces pombe expresses the CCAAT-binding factor Php4 in response to iron deprivation. Php4 forms a transcription complex with Php2,… Continue reading Schizosaccharomyces pombe Grx4 regulates the transcriptional repressor Php4 via [2Fe–2S] cluster binding
Leah Pandiscia, PhD
May 22, 2018
Herein, we present a novel synthetic strategy, to amino-acid-free peptide synthesis based on postpolymerization conversion, for chiral nonnatural polypeptides. Optically… Continue reading Synthesis of Nonnatural Helical Polypeptide via Asymmetric Polymerization and Reductive Cleavage of N–O Bond
Leah Pandiscia, PhD
May 22, 2018
The catalytic active site of Mn-specific superoxide dismutase (MnSOD) is organized around a redox-active Mn ion. The most highly conserved… Continue reading A Single Outer-Sphere Mutation Stabilizes apo-Mn Superoxide Dismutase by 35 °C and Disfavors Mn Binding
Leah Pandiscia, PhD
May 22, 2018
The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds… Continue reading Phytochemical characterization and biological activity of secondary metabolites from three Limonium species
Leah Pandiscia, PhD
May 22, 2018
Extensive screening for the antiproliferative activity of different compounds found in trees was performed by extracting the leaves of Aphananthe aspera (Thunb.)… Continue reading Antiproliferative constituents from Aphananthe asperaleaves
Leah Pandiscia, PhD
May 22, 2018
Through genetic engineering technology, catalase (CAT) and superoxide dismutase (SOD) have been separately fused to an elastin-like polypeptide (ELP). Thus,… Continue reading Co-Immobilization of Superoxide Dismutase with Catalase on Soft Microparticles Formed by Self-Assembly of Amphiphilic Poly(Aspartic Acid)
Leah Pandiscia, PhD
May 22, 2018
Mercury sulfide (HgS) nanoparticles (NPs) were prepared in the presence of water-soluble thiols as capping ligands in aqueous solutions. Chiral… Continue reading The effect of surface ligands on the optical activity of mercury sulfide nanoparticles
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018