Five new compounds were isolated from Penicillium sp. Y-5-2 including an austin derivative 4, four isocoumarins 9, 11, 12, and 13, together with two known isocoumarins 8 and 10, and… Continue reading Isolation and Antibiotic Screening of Fungi from a Hydrothermal Vent Site and Characterization of Secondary Metabolites from a Penicillium Isolate
Leah Pandiscia, PhD
May 22, 2018
Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the… Continue reading Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
Leah Pandiscia, PhD
May 22, 2018
Noncovalent, weak interactions in the second coordination sphere of the copper active site of Pseudoazurin (PAz) from Achromobacter cycloclastes were examined using… Continue reading Stabilization of protein structure through π–π interaction in the second coordination sphere of pseudoazurin
Leah Pandiscia, PhD
May 22, 2018
Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has… Continue reading Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
Leah Pandiscia, PhD
May 22, 2018
A series of cationic peptides with alternating hydrophilic and hydrophobic residues were elaborately designed and synthesized. These kinds of short… Continue reading Short Peptides Directing 1D Helical Arrays of Polyoxometalates with Controllable Pitches
Leah Pandiscia, PhD
May 22, 2018
G-quadruplex (G4) is involved in many biological processes, such as telomere function, gene expression and DNA replication. The selective isolation… Continue reading Naphthalene amine support for G-quadruplex isolation
Leah Pandiscia, PhD
May 22, 2018
Sensory hair cells rely on otoferlin as the calcium sensor for exocytosis and encoding of sound preferentially over the neuronal… Continue reading Otoferlin is a multivalent calcium-sensitive scaffold linking SNAREs and calcium channels
Leah Pandiscia, PhD
May 22, 2018
The HSL-like lipase encoding gene (Blip) from the polyextremophile Bacillus halodurans C-125 has been heterologously expressed in E.coli BL21(DE3). The enzyme is a monomer… Continue reading Functional characterization of hormone sensitive-like lipase from Bacillus halodurans: synthesis and recovery of pNP-laurate with high yields
Leah Pandiscia, PhD
May 22, 2018
ight new alkaloids, including three pairs of enantiomers (+)-(2′S,3′R)-clauselansine A (1a) and (−)-(2′R,3′S)-clauselansine A (1b); (+)-(2′S,3′R)-clauselansine B (2a) and (−)-(2′R,3′S)-clauselansine… Continue reading Alkaloids from the stems of Clausena lansium and their neuroprotective activity
Leah Pandiscia, PhD
May 22, 2018
Edifenphos is an important organophosphate pesticide with many antifungal and anti-insecticidal properties but it may cause potential hazards to human… Continue reading Deciphering the mechanism of interaction of edifenphos with calf thymus DNA
Leah Pandiscia, PhD
May 22, 2018
A new N-methoxypyridone analog (1), together with four known compounds, was isolated from the co-culture of Hawaiian endophytic fungi Camporesia sambuci FT1061 and Epicoccum… Continue reading A New N-methoxypyridone from the Co-Cultivation of Hawaiian Endophytic Fungi Camporesia sambuci FT1061 and Epicoccum sorghinum FT1062
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
Leah Pandiscia, PhD
May 22, 2018
A combination of computation techniques and peptide mutants have been used to determine the binding site and amino acid residues… Continue reading Characterization and Evaluation of Key Sites in the Peptide Inhibitor of TAB1/p38α Interaction
Leah Pandiscia, PhD
May 22, 2018
Synthetic proteins bearing site-specific posttranslational modifications have revolutionized our understanding of their biological functions in vitro and in vivo. One such modification, O-GlcNAcylation,… Continue reading The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels
Leah Pandiscia, PhD
May 22, 2018
The interactions of bovine serum albumin (BSA) with aggregates of cationic polymers, i.e. quaternized poly(chloromethyl styrene) chains (QIm-PCMS), in aqueous solutions are… Continue reading Tuning the solution organization of cationic polymers through interactions with bovine serum albumin
Leah Pandiscia, PhD
May 22, 2018
Prevention and therapeutic strategies for various neurodegenerative diseases focus on inhibiting protein fibrillation, clearing aggregated protein plaques from the brain,… Continue reading Poly(trehalose) Nanoparticles Prevent Amyloid Aggregation and Suppress Polyglutamine Aggregation in a Huntington’s Disease Model Mouse
Leah Pandiscia, PhD
May 22, 2018
Herein, supramolecular gels from L-aspartic acid-based perylenebisimides (APBI) and various isomeric benzene dicarboxylic acids (o-phthalic acid, OPA; isophthalic acid, IPA and… Continue reading Formation of supermolecular chiral gels from L-aspartic acid-based perylenebisimides and benzene dicarboxylic acids
Leah Pandiscia, PhD
May 22, 2018